LIN28B (gene)

LIN28B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4A4I
Identifiers
Aliases	LIN28B, CSDD2, lin-28 homolog B
External IDs	MGI: 3584032 HomoloGene: 47607 GeneCards: LIN28B
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.3-q21 Start 104,936,616 bp[1] End 105,083,332 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B2 Start 45,376,620 bp[2] End 45,486,395 bp[2]
Gene ontology Molecular function • DNA binding • zinc ion binding • protein binding • metal ion binding • RNA binding • nucleic acid binding Cellular component • cytoplasm • cell nucleus • nucleolus • cytosol Biological process • pre-miRNA processing • miRNA catabolic process • gene silencing by RNA • regulation of transcription, DNA-templated • RNA 3'-end processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	389421	380669
Ensembl	ENSG00000187772	ENSMUSG00000063804
UniProt	Q6ZN17	Q45KJ6
RefSeq (mRNA)	NM_001004317	NM_001031772 NM_001033152
RefSeq (protein)	NP_001004317	NP_001026942
Location (UCSC)	Chr 6: 104.94 – 105.08 Mb	Chr 10: 45.38 – 45.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. ^[5]

Function

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.