LCMT2

LCMT2
Identifiers
AliasesLCMT2, PPM2, TYW4, leucine carboxyl methyltransferase 2
External IDsMGI: 1353659 HomoloGene: 19642 GeneCards: LCMT2
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q15.3Start43,323,649 bp[1]
End43,330,605 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9836

329504

Ensembl

ENSG00000168806

ENSMUSG00000074890

UniProt

O60294

Q8BYR1

RefSeq (mRNA)

NM_014793

NM_177846

RefSeq (protein)

NP_055608

NP_808514

Location (UCSC)Chr 15: 43.32 – 43.33 MbChr 2: 121.13 – 121.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.[5][6][7]

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G(1)/S and G(2)/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168806 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074890 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ↑ Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.
  7. 1 2 "Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2".

Further reading

  • De Baere I, Derua R, Janssens V, et al. (2000). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Marwick JA, Kirkham P, Gilmour PS, et al. (2003). "Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells". Ann. N. Y. Acad. Sci. 973: 278–83. doi:10.1111/j.1749-6632.2002.tb04649.x. PMID 12485877.
  • Ng CC, Arakawa H, Fukuda S, et al. (2003). "p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1". Oncogene. 22 (28): 4449–58. doi:10.1038/sj.onc.1206586. PMID 12853982.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kawamata N, Inagaki N, Mizumura S, et al. (2005). "Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders". Eur. J. Haematol. 74 (5): 424–9. doi:10.1111/j.1600-0609.2005.00417.x. PMID 15813917.
  • Noma A, Kirino Y, Ikeuchi Y, Suzuki T (2006). "Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA". EMBO J. 25 (10): 2142–54. doi:10.1038/sj.emboj.7601105. PMC 1462984. PMID 16642040.
  • Liu FY, Qi JP, Xu FL, Wu AP (2006). "Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor". World J. Gastroenterol. 12 (26): 4161–5. PMID 16830365.
  • Moon SK, Choi YH, Kim CH, Choi WS (2006). "p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1". Biochem. Biophys. Res. Commun. 350 (3): 662–8. doi:10.1016/j.bbrc.2006.09.092. PMID 17026958.


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