LBX1

LBX1
Identifiers
Aliases	LBX1, HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1
External IDs	MGI: 104867 HomoloGene: 4784 GeneCards: LBX1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	101,229,794 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	45,235,812 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding; • sequence-specific DNA binding; • DNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding;
Cellular component	• cell nucleus; • transcription factor complex;
Biological process	• multicellular organism development; • heart looping; • anatomical structure morphogenesis; • cell differentiation; • muscle organ development; • neuron fate commitment; • spinal cord motor neuron differentiation; • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification; • regulation of transcription, DNA-templated; • negative regulation of neuron differentiation; • neuron fate determination; • transcription, DNA-templated; • nervous system development; • negative regulation of cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	10660
	16814
	ENSG00000138136
	ENSMUSG00000025216
	P52954
	P52955
	NM_006562
	NM_010691
	NP_006553
	NP_034821
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.^[5]^[6]

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138136 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025216 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M (Jul 1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes". Mech Dev. 53 (3): 345–56. doi:10.1016/0925-4773(95)00450-5. PMID 8645601.
1 2 "Entrez Gene: LBX1 ladybird homeobox 1".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
de Mollerat XJ, Gurrieri F, Morgan CT, et al. (2004). "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24". Hum. Mol. Genet. 12 (16): 1959–71. doi:10.1093/hmg/ddg212. PMID 12913067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kozmik Z, Holland LZ, Schubert M, et al. (2001). "Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm". Genesis. 29 (4): 172–9. doi:10.1002/gene.1021. PMID 11309850.
Moretti P, Simmons P, Thomas P, et al. (1994). "Identification of homeobox genes expressed in human haemopoietic progenitor cells". Gene. 144 (2): 213–9. doi:10.1016/0378-1119(94)90380-8. PMID 7518789.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138136 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025216 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8645601-5] Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M (Jul 1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes". Mech Dev. 53 (3): 345–56. doi:10.1016/0925-4773(95)00450-5. PMID 8645601.

[entrez-6] 1 2 "Entrez Gene: LBX1 ladybird homeobox 1".

LBX1

References

Further reading