LARP4

LARP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLARP4, PP13296, La ribonucleoprotein domain family member 4
External IDsMGI: 2443114 HomoloGene: 19173 GeneCards: LARP4
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

113251

207214

Ensembl

n/a

ENSMUSG00000023025

UniProt

Q71RC2

Q8BWW4

RefSeq (mRNA)

NM_001024526
NM_001080948
NM_001284521
NM_001284522
NM_001284523

RefSeq (protein)

NP_001019697
NP_001074417
NP_001271450
NP_001271451
NP_001271452

Location (UCSC)n/aChr 15: 99.97 – 100.02 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

La-related protein 4 is a protein that in humans is encoded by the LARP4 gene.[4][5] LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.[6]

LARP4 is known to regulate cancer cell migration and invasion by altering cell shape.[7] It is also reported to be a glioma tumor suppressor.[8]


References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023025 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  5. ↑ "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
  6. ↑ Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
  7. ↑ Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
  8. ↑ Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

Further reading

  • Stavraka C, Blagden S (October 2015). "The La-Related Proteins, a Family with Connections to Cancer". Biomolecules. 5 (4): 2701–22. doi:10.3390/biom5042701. PMC 4693254. PMID 26501340.
  • Kralovics R, Skoda RC (January 2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Reviews. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
  • Puigdecanet E, Espinet B, Villa O, Florensa L, Besses C, Serrano S, Solé F (May 2006). "Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia". Cancer Genetics and Cytogenetics. 167 (1): 39–42. doi:10.1016/j.cancergencyto.2005.08.016. PMID 16682284.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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