Krzysztof Palczewski

Krzysztof Palczewski
Born 1957
Syców, Poland
Citizenship Polish
Alma mater University of Wrocław, Wrocław University of Technology
Known for Rhodopsin
Awards

Humboldt Research Award
Prize of the Foundation for Polish Science (2012)[1]
Arvo Friedenwald award (2014) [2]
Beckman-Argyros award in Vision Research (2015)

Bressler Award in Vision Science (2015)[3]
Scientific career
Fields Biochemistry
Institutions Case Western Reserve University
Doctoral advisor Marian Kochman
Website Link

Krzysztof Palczewski is a Polish biochemist working at Case Western Reserve University in Cleveland, Ohio.[4] In 2012 he was awarded Prize of the Foundation for Polish Science, the most prestigious scientific award for Polish scientists, for characterizing crystal structures of native and activated G protein-coupled receptor, rhodopsin, involved in eyesight.[5]

His MS and PhD are from the University of Wroclaw and Technical University of Wroclaw respectively (Poland), working with Dr. M. Kochman. His early posts were at the University of Florida and the Oregon Health Sciences University. Dr. Palczewski completed much of his pivotal research at the University of Washington and moved to become the Chair and John H. Hord professor of Pharmacology at Case Western Reserve University in 2005.[6] In 2016 he was appointed as Distinguished Professor of the Case Western Reserve University.

He is the founder of two drug discovery companies, Polgenix and Retinagenix.[7]

Research interests

Palczewski's research interest lie in mapping the Visual Transduction System. His work with determining the crystal structure of rhodopsin has given new insight into the function of G protein receptors. Furthermore, his work on visual cycle has led to revolutionary advances in understanding hereditary blindness, leading to implementation of novel pharmacological treatments that can slow retinal degeneration in adults.[8][9] His team's latest efforts indicate that repetitive 2-photon imaging of the human eye can safely reveal the visual system's subcellular architecture and that humans can detect infrared light due to simultaneous 2-photon absorption. [10] [11]

References

Notes

  1. ↑ "Prof. Krzysztof Palczewski - FNP Prize 2012 laureate".
  2. ↑ Polans, Arthur S. (2014). "Introducing Krzysztof Palczewski, the 2014 Recipient of the Friedenwald Award". Investigative Opthalmology & Visual Science. 55 (10): 6649–50. doi:10.1167/iovs.14-14843. PMID 25338685.
  3. ↑ "Lighthouse Guild | Bressler Prize in Vision Science Recipients".
  4. ↑ http://pharmacology.case.edu/department/Faculty/Primary/Pages/Palczewski/default.aspx
  5. ↑ "Prof. Krzysztof Palczewski - FNP Prize 2012 laureate".
  6. ↑ http://pharmacology.case.edu/department/Faculty/Primary/Pages/Palczewski/default.aspx
  7. ↑ http://archive.sciencewatch.com/may-june2003/sw_may-june2003_page3.htm
  8. ↑ Jacobson, S. G.; Aleman, T. S.; Cideciyan, A. V.; Sumaroka, A.; Schwartz, S. B.; Windsor, E. A. M.; Traboulsi, E. I.; Heon, E.; Pittler, S. J.; Milam, A. H.; Maguire, A. M.; Palczewski, K.; Stone, E. M.; Bennett, J. (2005). "Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success". Proceedings of the National Academy of Sciences. 102 (17): 6177–6182. doi:10.1073/pnas.0500646102. PMC 1087926. PMID 15837919.
  9. ↑ Maeda, Akiko (2006). "Aberrant Metabolites in Mouse Models of Congenital Blinding Diseases: Formation and Storage of Retinyl Esters†". Biochemistry. 45 (13): 4210–4219. doi:10.1021/bi052382x. PMC 1560103. PMID 16566595.
  10. ↑ Palczewska, Grazyna; Dong, Zhiqian; Golczak, Marcin; Hunter, Jennifer J.; Williams, David R.; Alexander, Nathan S.; Palczewski, Krzysztof (2014). "Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye". Nature Medicine. 20 (7): 785–789. doi:10.1038/nm.3590. PMC 4087080. PMID 24952647.
  11. ↑ Palczewska, Grazyna; Vinberg, Frans; Stremplewski, Patrycjusz; Bircher, Martin P.; Salom, David; Komar, Katarzyna; Zhang, Jianye; Cascella, Michele; Wojtkowski, Maciej; Kefalov, Vladimir J.; Palczewski, Krzysztof (2014). "Human infrared vision is triggered by two-photon chromophore isomerization". Proceedings of the National Academy of Sciences. 111 (50): E5445–E5454. doi:10.1073/pnas.1410162111. PMC 4273384. PMID 25453064.

Bibliography

  • Vertebrate Phototransduction and the Visual Cycle, Krzysztof Palczewski, Academic Press (2000), ISBN 0-12-182217-6
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