Kenneth B. Storey

Kenneth Storey
Born Kenneth Bruce Storey
(1949-10-23) October 23, 1949
Taber, Alberta, Canada
Residence Ottawa, Ontario, Canada
Citizenship Canadian
Awards Royal Society of Canada Fellow (1990)
Flavelle Medal (2010)
Fry Medal (2011)
Cryo-Fellow (2012)
Scientific career
Fields Molecular Physiology
Biochemistry
Biochemical Adaptation
Institutions Carleton University, Canada
Doctoral advisor Peter W. Hochachka
Doctoral students Kyle Biggar, William G. Willmore

Kenneth B. Storey, Ph.D. FRSC (born October 23, 1949) is a Canadian scientist whose work draws from a variety of fields including biochemistry and molecular biology. He is a Professor of Biology, Biochemistry and Chemistry at Carleton University in Ottawa, Canada. Storey has a world-wide reputation for his research on biochemical adaptation - the molecular mechanisms that allow animals to adapt to and endure severe environmental stresses such as deep cold, oxygen deprivation, and desiccation.[1]

Biography

Kenneth Storey studied biochemistry at the University of Calgary (B.Sc. '71) and zoology at the University of British Columbia (Ph.D. '74).[2][3] Storey is a Professor of Biochemistry, cross-appointed in the Departments of Biology, Chemistry and Neuroscience and holds the Canada Research Chair in Molecular Physiology at Carleton University in Ottawa, Canada.[4]

Storey is an elected fellow of the Royal Society of Canada,[5] of the Society for Cryobiology[6] and of the American Association for the Advancement of Science. He has won fellowships and awards for research excellence including the Fry medal from the Canadian Society of Zoologists (2011), the Flavelle medal from the Royal Society of Canada (2010), Ottawa Life Sciences Council Basic Research Award (1998), a Killam Senior Research Fellowship (1993–1995), the Ayerst Award from the Canadian Biochemical Society (1989), an E.W.R. Steacie Memorial Fellowship from the Natural Sciences and Engineering Research Council of Canada (1984–1986), and four Carleton University Research Achievement Awards. Storey is the author of over 844 research articles, the editor of seven books, has given over 500 talks at conferences and institutes worldwide, and organized numerous international symposia.[7]

Research

Storey is one of the most cited researchers in the world.[8] Storey's research includes studies of enzyme properties, gene expression, protein phosphorylation, and cellular signal transduction mechanisms to seek out the basic principles of how organisms endure and flourish under extreme conditions. He is particularly known within the field of cryobiology for his studies of animals that can survive freezing, especially the frozen "frog-sicles" (Rana sylvatica) that have made his work popular with multiple TV shows and magazines.[9][10][11] Storey's studies of the adaptations that allow frogs, insects, and other animals to survive freezing have made major advances in the understanding of how cells, tissues and organs can endure freezing.[11] Storey was also responsible for the discovery that some turtle species are freeze tolerant: newly hatched painted turtles that spend their first winter on land (Chrysemys picta marginata & C. p. bellii). These turtles are unique as they are the only reptiles, and highest vertebrate life form, known to tolerate prolonged natural freezing of extracellular body fluids during winter hibernation.[12] These advances may aid the development of organ cryopreservation technology.[4] A second area of his research is metabolic rate depression - understanding the mechanisms by which some animals can sharply reduce their metabolism and enter a state of hypometabolism or torpor that allows them to survive over the long term under difficult environmental stresses. His studies have identified molecular mechanisms that underlie metabolic arrest across phylogeny and that support phenomena including mammalian hibernation, estivation, and anoxia and ischemia tolerance. Control mechanisms include transcription factor changes that alter gene expression, and reversible phosphorylation of key metabolic enzymes by protein kinases and protein phosphatases. These studies across multiple species also hold key applications for medical science, particularly for preservation technologies that aim to extend the survival time of excised organs in cold or frozen storage.[4] Additional applications include insights into hyperglycemia in metabolic syndrome and diabetes,[13] and anoxic and ischemic damage caused by heart attack and stroke.[14]

Website

[Main Page]

Personal Profile

Selected recent publications

Full list on Google Scholar

Books

  • Storey, K.B.; Tanino, K.K., eds. (2012). Temperature Adaptation in a Changing Climate. Walllingford: CABI Publishers.
  • Storey, K.B. (2004). Functional Metabolism: Regulation and Adaptation. Hoboken, NJ: Wiley-Liss.

Selected Review Articles

  • Storey, K.B. (2015). "Regulation of hypometabolism: insights into epigenetic controls". J. Exp. Biol. 218: 150–159. doi:10.1242/jeb.106369. PMID 25568462.
  • Krivoruchko, A.; Storey, K.B. (2015). "Turtle anoxia tolerance: biochemistry and gene regulation". Biochim. Biophys. Acta. 1850 (6): 1188–1196. doi:10.1016/j.bbagen.2015.02.001. PMID 25662819.
  • Biggar, K.K.; Storey, K.B. (2014). "New approaches to comparative and animal stress biology research in the post-genomic era: a contextual overview". Comput.Struct. Biotech. J. 11: 138–146. doi:10.1016/j.csbj.2014.09.006. PMC 4232569. PMID 25408848.
  • Storey, K.B.; Wu, C.-W. (2013). "Stress response and adaptation: a new molecular toolkit for the 21st century". Comp. Biochem. Physiol. A. 165 (4): 417–428. doi:10.1016/j.cbpa.2013.01.019. PMID 23376623.
  • Storey, K.B.; Storey, J.M. (2013). "Molecular biology of freeze tolerance in animals". Comp. Physiol. 3: 1283–308. doi:10.1002/cphy.c130007. PMID 23897687.
  • Storey, K.B.; Storey, J.M. (2012). "Aestivation: signaling and hypometabolism". J. Exp. Biol. 215: 1425–1433. doi:10.1242/jeb.054403. PMID 22496277.
  • Storey, K.B.; Storey, J.M. (2012). "Insect cold hardiness: recent advances in metabolic, gene and protein adaptation". Can. J. Zool. 90 (Pt 9): 456–475. doi:10.1139/Z2012-011.
  • Storey, K.B.; Storey, J.M. (2011). "Hibernation: Poikilotherms". Encyclopedia of Life Science. Chichester: John Wiley & Sons.
  • Storey, K.B. (2010). "Out cold: biochemical regulation of mammalian hibernation". Gerontology. 56: 220–230. doi:10.1159/000228829. PMID 19602865.
  • Biggar, K.K.; Storey, K.B. (2011). "The emerging roles of microRNAs in the molecular responses of metabolic rate depression". J. Mol. Cell Biol. 3 (3): 167–175. doi:10.1093/jmcb/mjq045. PMID 21177365.
  • Storey, K.B.; Storey, J.M. (2010). "Metabolic rate depression: the biochemistry of mammalian hibernation". Adv. Clin. Chem. 52: 77–108. doi:10.1016/S0065-2423(10)52003-1. PMID 21275340.

Boards

  • Journal of Comparative Physiology B (since 1994)
  • PeerJ (since 2012)
  • Genomics, Proteomics and Bioinformatics (since 2014)
  • Past member: American Journal of Physiology, Molecular Physiology, Copeia, J. Experimental Zoology, Environmental Reviews, Biochemistry & Cell Biology, Cryo-Letters, Experimental Biology Online

Professional Positions

  • Canada Research Chair (Tier 1) in Molecular Physiology, Carleton University, Ottawa (2001–present)[4]
  • Professor of Biochemistry, Departments of Biology and Chemistry, Carleton University, Ottawa (1989–present)
  • Professor of Biochemistry and Biology, Carleton University, Ottawa (1985-1989)
  • Associate Professor of Biochemistry and Biology, Carleton University, Ottawa (1979-1985)
  • Assistant Professor of Zoology, Duke University, Durham, North Carolina (1974-1979)

Professional Honours

  • Distinguished editorial board member of Genomics, Proteomics & Bioinformatics (2017)
  • Carleton University Research Achievement Award (2016, 2008, 2003, 1998, 1992 and 1989)
  • Fellow of the Society for Cryobiology, elected (2012)
  • Fry Award - Canadian Society of Zoologists (2011)
  • Flavelle Medal of the Royal Society of Canada (2010)
  • Graduate mentor award - Carleton University (inaugural 2010)
  • Distinguished Alumni Award, University of Calgary (2007)
  • Professor Extraordinary, Botany & Zoology, Stellenbosch University, S. Africa (2005–2007)
  • ISI Highly Cited Researcher (2004–present)
  • Public Awareness Prize, Canadian Society of Zoologists (2000)
  • Ottawa Life Sciences Council, Basic Research Award (1998)
  • Fellow of the American Association for the Advancement of Science, elected (1997)
  • Killam Senior Research Fellowship (1993–1995)
  • Fellow of the Royal Society of Canada, elected (1990)[5]
  • Ayerst Award, Canadian Biochemical Society (1989)
  • E.W.R. Steacie Memorial Fellowship, NSERC Canada (1984–1986)

Recent Research Activities

  • 2018 - Visiting Researcher Department of Zoology, University of Pretoria, South Africa
  • 2014 - Visiting researcher, King Abdullah University of Science & Technology, Saudi Arabia
  • 2012 - Visiting lecturer & researcher, St. George’s University, Grenada
  • 2011 - Research scientist, R/V New Horizon expedition, Sea of Cortez, Mexico
  • 2011 - Visiting lecturer & researcher, St. George’s University, Grenada
  • 2010 - Visiting researcher, Sport and Exercise Science, U. Coventry, UK
  • 2008 - Visiting researcher, Sable Systems International, Las Vegas, Nevada
  • 2007 - Visiting researcher, Dept. Botany and Zoology, Stellenbosch University, S. Africa
  • 2005 - Visiting researcher, Physiologisches Institut, Universitat Zuerich-Irchel, Switzerland
  • 2004 - Visiting researcher, Dept. Botany and Zoology, Stellenbosch University, S. Africa
  • 1999 - Visiting researcher, Kyoto Institute of Technology, Kyoto, Japan
  • 1998 - Visiting researcher, Hofstra University, Hempstead, New York
  • 1998 - Visiting researcher, Harvard Medical School (F. Bunn lab) and Massachusetts General Hospital (D. Brown lab), Boston, Mass.
  • 1997 - Visiting researcher, Dept. of Mechanical Engineering and Lawrence Berkeley Labs, University of California, Berkeley, CA.
  • 1994 - Visiting scientist, McMurdo Station, Antarctica
  • 1993 - Visiting researcher, Harvard University Medical School, Boston, MA
  • 1992 - Visiting researcher, Dept. of Mechanical Engineering and Lawrence Berkeley Labs, University of California, Berkeley, CA.
  • 1991 - Visiting researcher, Department of Biochemistry, University of Victoria, Victoria, BC
  • 1990 - Visiting researcher, University of Massachusetts, Worcester, MA.

References

  1. ↑ "Kenneth Storey Bio". Ask the Scientists. PBS.
  2. ↑ http://kenstoreylab.com/?page_id=4
  3. ↑ https://www.researchgate.net/profile/Kenneth_Storey/info
  4. 1 2 3 4 "How research in Ottawa can preserve organs for transplant in the future" (PDF). Carleton University.
  5. 1 2 "Royal Society of Canada members at Carleton University". Carleton University. Archived from the original on 2009-08-29.
  6. ↑ "Society for Cryobiology".
  7. ↑ "STOREY Lab".
  8. ↑ https://www.researchgate.net/profile/Kenneth_Storey
  9. ↑ McIlroy, Anne (3 December 2009). "Frozen frogs thaw out and hop away". The Globe and Mail. Archived from the original on 22 August 2010. Retrieved 15 January 2010.
  10. ↑ "Melted Frogsicle" (Silverlight video). Discovery Channel.
  11. 1 2 "Freeze and thaw frogs" (Silverlight video). Discovery Channel.
  12. ↑ Storey, KB; Storey, JM; Brooks, SP; Churchill, TA; Brooks, RJ (1988). "Hatchling turtles survive freezing during winter hibernation". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8350–4. doi:10.1073/pnas.85.21.8350. PMC 282428. PMID 3186730.
  13. ↑ http://sandrablakeslee.com/articles/ice_age_diabetes_may05.php
  14. ↑ http://health.usnews.com/usnews/health/articles/050523/23hibernate.htm
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