Kelch-like protein 2

KLHL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLHL2, ABP-KELCH, MAV, MAYVEN, kelch like family member 2
External IDsMGI: 1924363 HomoloGene: 21416 GeneCards: KLHL2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.3Start165,207,618 bp[1]
End165,323,156 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

11275

77113

Ensembl

ENSG00000109466

ENSMUSG00000031605

UniProt

O95198

Q8JZP3

RefSeq (mRNA)

NM_001161521
NM_001161522
NM_007246
NM_001331023
NM_001331024

NM_178633

RefSeq (protein)

NP_001154993
NP_001154994
NP_001317952
NP_001317953
NP_009177

NP_848748

Location (UCSC)Chr 4: 165.21 – 165.32 MbChr 8: 64.74 – 64.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kelch-like family member 2 is a protein that in humans is encoded by the KLHL2 gene.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000109466 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031605 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Kelch-like family member 2".

Further reading

  • Tseng LA, Bixby JL (Aug 2011). "Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis". Molecular and Cellular Neurosciences. 47 (4): 254–64. doi:10.1016/j.mcn.2011.04.005. PMC 3137755. PMID 21549840.
  • Korutla L, Wang P, Jackson TG, Mackler SA. "NAC1, a POZ/BTB protein that functions as a corepressor". Neurochemistry International. 54 (3–4): 245–52. doi:10.1016/j.neuint.2008.12.008. PMID 19121354.
  • Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC (Sep 2005). "Role of Mayven, a kelch-related protein in oligodendrocyte process formation". Journal of Neuroscience Research. 81 (5): 622–31. doi:10.1002/jnr.20588. PMID 16035103.
  • Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. "Update on the Kelch-like (KLHL) gene family". Human Genomics. 7: 13. doi:10.1186/1479-7364-7-13. PMC 3658946. PMID 23676014.
  • Mai A, Jung SK, Yonehara S (Oct 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
  • Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T (Jun 2014). "Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation". The Biochemical Journal. 460 (2): 237–46. doi:10.1042/BJ20140153. PMC 4019986. PMID 24641320.
  • Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S (Jul 1999). "Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain". Molecular Biology of the Cell. 10 (7): 2361–75. doi:10.1091/mbc.10.7.2361. PMC 25454. PMID 10397770.
  • Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S (Mar 2005). "Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells". Oncogene. 24 (14): 2398–409. doi:10.1038/sj.onc.1208466. PMID 15735724.
  • Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S (Aug 2013). "KLHL2 interacts with and ubiquitinates WNK kinases". Biochemical and Biophysical Research Communications. 437 (3): 457–62. doi:10.1016/j.bbrc.2013.06.104. PMID 23838290.


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