KLC3

KLC3
Identifiers
AliasesKLC3, KLC2, KLC2L, KLCt, KNS2B, kinesin light chain 3
External IDsMGI: 1277971 HomoloGene: 14899 GeneCards: KLC3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.32Start45,333,434 bp[1]
End45,351,520 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

147700

232943

Ensembl

ENSG00000104892

ENSMUSG00000040714

UniProt

Q6P597

Q91W40

RefSeq (mRNA)

NM_145275
NM_177417

NM_001286038
NM_001286039
NM_146182

RefSeq (protein)

NP_803136

NP_001272967
NP_001272968
NP_666294

Location (UCSC)Chr 19: 45.33 – 45.35 MbChr 7: 19.39 – 19.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.[5]

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.[5]

Interactions

KLC3 has been shown to interact with YWHAH.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104892 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040714 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: KLC3 kinesin light chain 3".
  6. ↑ Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

Further reading

  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Zhang Y, Oko R, van der Hoorn FA (Nov 2004). "Rat kinesin light chain 3 associates with spermatid mitochondria". Developmental Biology. 275 (1): 23–33. doi:10.1016/j.ydbio.2004.07.014. PMC 3138780. PMID 15464570.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn FA (May 2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". The Journal of Biological Chemistry. 278 (18): 16159–68. doi:10.1074/jbc.M213126200. PMC 3178653. PMID 12594206.
  • Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". The Journal of Cell Biology. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070. PMID 12427867.
  • Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.
  • Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (May 2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biology of Reproduction. 64 (5): 1320–30. doi:10.1095/biolreprod64.5.1320. PMC 3161965. PMID 11319135.
  • Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.
  • Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122.
  • Lamerdin JE, Stilwagen SA, Ramirez MH, Stubbs L, Carrano AV (Jun 1996). "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes". Genomics. 34 (3): 399–409. doi:10.1006/geno.1996.0303. PMID 8786141.


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