KIF1C

KIF1C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIF1C, LTXS1, SATX2, SAX2, SPAX2, SPG58, kinesin family member 1C
External IDsMGI: 1098260 HomoloGene: 4821 GeneCards: KIF1C
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.2Start4,997,948 bp[1]
End5,028,401 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10749

16562

Ensembl

ENSG00000129250

ENSMUSG00000020821

UniProt

O43896

O35071

RefSeq (mRNA)

NM_006612

NM_153103

RefSeq (protein)

NP_006603

NP_694743

Location (UCSC)Chr 17: 5 – 5.03 MbChr 11: 70.7 – 70.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene.[5][6] Kif1C is a fast, non-processive, plus-end directed microtubule motor.[7] Kif1C transports α5β1-integrins in human cells.[8] Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function.[9]

Interactions

KIF1C has been shown to interact with PTPN21[5] and YWHAG.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000129250 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020821 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R (Sep 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J Biol Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.
  6. ↑ "Entrez Gene: KIF1C kinesin family member 1C".
  7. ↑ Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R (September 2001). "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". EMBO J. 20 (18): 5101–13. doi:10.1093/emboj/20.18.5101. PMC 125638. PMID 11566875.
  8. ↑ Theisen U, Straube E, Straube A (December 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Dev. Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.
  9. ↑ Kazuo N, Yosuke T, Yosuke T, Terunaga N, Takao N, Yasuko N, Mitsutoshi S, Nobutaka H (February 2002). "Molecular Motor KIF1C Is Not Essential for Mouse Survival and Motor-Dependent Retrograde Golgi Apparatus-to-Endoplasmic Reticulum Transport". Molecular and Cell Biology. 38 (13): 866–873. doi:10.1128/MCB.22.3.866-873.2002. PMC 133549.
  10. ↑ Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.

Further reading

  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Dorner C, Ullrich A, Häring HU, Lammers R (1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kopp P, Lammers R, Aepfelbacher M, et al. (2006). "The Kinesin KIF1C and Microtubule Plus Ends Regulate Podosome Dynamics in Macrophages". Mol. Biol. Cell. 17 (6): 2811–23. doi:10.1091/mbc.E05-11-1010. PMC 1474789. PMID 16554367.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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