KDM8

KDM8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM8, JMJD5, lysine demethylase 8
External IDsMGI: 1924285 HomoloGene: 49791 GeneCards: KDM8
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p12.1Start27,203,495 bp[1]
End27,221,768 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

79831

77035

Ensembl

ENSG00000155666

ENSMUSG00000030752

UniProt

Q8N371

Q9CXT6

RefSeq (mRNA)

NM_001145348
NM_024773

NM_029842

RefSeq (protein)

NP_001138820
NP_079049

NP_084118

Location (UCSC)Chr 16: 27.2 – 27.22 MbChr 7: 125.44 – 125.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene. [5]

Function

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155666 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030752 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. "Entrez Gene: Lysine demethylase 8". Retrieved 2016-04-09.

Further reading

  • Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG (2006). "Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice". EMBO J. 25 (14): 3422–31. doi:10.1038/sj.emboj.7601215. PMC 1523184. PMID 16858412.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.