KDM6B
Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. [5]
Regulation during differentation
KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.[6]
Small molecule inhibition
A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000132510 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018476 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.
- ↑ Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.
- ↑ Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response". Nature. 488 (7411): 404–408. doi:10.1038/nature11262. ISSN 1476-4687. PMC 4691848. PMID 22842901.
Further reading
- Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature. 449 (7163): 731–4. doi:10.1038/nature06145. PMID 17713478.
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.