KATNA1

KATNA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKATNA1, katanin catalytic subunit A1
External IDsMGI: 1344353 HomoloGene: 56014 GeneCards: KATNA1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q25.1Start149,594,873 bp[1]
End149,648,972 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

11104

23924

Ensembl

ENSG00000186625

ENSMUSG00000019794

UniProt

O75449

Q9WV86

RefSeq (mRNA)

NM_001204076
NM_007044

NM_011835

RefSeq (protein)

NP_001191005
NP_008975

n/a

Location (UCSC)Chr 6: 149.59 – 149.65 MbChr 10: 7.73 – 7.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.[5][6]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186625 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019794 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.
  6. 1 2 "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

Further reading

  • McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885.
  • McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell Sci. 109 (3): 561–7. PMID 8907702.
  • Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
  • Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron". J. Cell Biol. 145 (2): 305–15. doi:10.1083/jcb.145.2.305. PMC 2133110. PMID 10209026.
  • Syu LJ, Saltiel AR (1999). "Lipotransin: a novel docking protein for hormone-sensitive lipase". Mol. Cell. 4 (1): 109–15. doi:10.1016/S1097-2765(00)80192-6. PMID 10445032.
  • McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin". J. Cell Sci. 113 (9): 1623–33. PMID 10751153.
  • Buster D, McNally K, McNally FJ (2002). "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis". J. Cell Sci. 115 (Pt 5): 1083–92. PMID 11870226.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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