In molecular biology, JPX transcript, XIST activator (non-protein coding), also known as Jpx, is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the Xist gene.[2] Jpx upregulates expression of Xist.[3]
References
- ↑ "Human PubMed Reference:".
- ↑ Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine". Genome Res. 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731. PMID 12045143.
- ↑ Tian D, Sun S, Lee JT (2010). "The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation". Cell. 143 (3): 390–403. doi:10.1016/j.cell.2010.09.049. PMC 2994261. PMID 21029862.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tsuritani K, Irie T, Yamashita R, et al. (2007). "Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes". Genome Res. 17 (7): 1005–14. doi:10.1101/gr.6030107. PMC 1899111. PMID 17567985.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kolesnikov NN, Elisafenko EA (2010). "[Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]". Genetika. 46 (10): 1386–91. PMID 21254562.
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