John F. Kurtzke

John Kurtzke
Born John Francis Kurtzke
September 14, 1926
Brooklyn, New York City, New York
Died December 1, 2015(2015-12-01) (aged 89)
Falls Church, Virginia
Alma mater Weill Cornell Medical College
Known for Expanded Disability Status Scale
Awards 1999 Charcot Award, 1997 Dystel Prize
Scientific career
Fields Neurology, Neuroepidemiology
Institutions Georgetown University
Notes

John Francis Kurtzke (September 14, 1926 – December 1, 2015) was a neuroepidemiologist and Professor of Neurology at Georgetown University who is best known for his creation of the Expanded Disability Status Scale and for his research on multiple sclerosis (MS).[1] After graduating from Cornell University Medical College in 1952, Dr. Kurtzke started his career in the field of Neurology as Chief of the Neurology Service at the Veteran’s Affairs (VA) Medical Centers in Coatesville, PA, from 1956 to 1963, and then in Washington, DC, from 1963 to 1995, where he became Professor of Neurology at Georgetown University. Until his death he was Professor Emeritus at Georgetown University.

Kurtzke disability status scale KDSS
Kurtzke 1983 map of Multiple sclerosis in the USA
Kurtzke 1983 map of Multiple sclerosis in the world
Kurtzke_map_of_MS_in_Scandinavia
Kurtzke map of Faroe Islands MS cases

Most of his work dealt with multiple sclerosis (MS). In particular, Dr Kurtzke is widely known for his Expanded Disability Status Scale or EDSS (a method of quantifying disability in multiple sclerosis)[2] and for his pioneering work in the field of neuroepidemiology, a branch of epidemiology he helped to establish in 1967 with Dr. Len Kurland and Dr. Milton Alter.[3]

He was a leading world expert on geographical patterns of prevalence of multiple sclerosis.[4][5][6] Kurtzke's results have played a major role in promoting the study of the viral component of MS susceptibility.[7]

The author of more than 200 peer-reviewed articles,[8][9][10] he has received several awards including the 1999 Charcot Award by the Multiple Sclerosis International Federation[11] and the 1997 Dystel prize for MS research awarded by the American Academy of Neurology.[12]

In 2009, the Consortium of Multiple Sclerosis Centers (CMSC) and the American Academy of Neurology Foundation (AANF) have created the John F. Kurtzke, MD, FAAN, Clinician-Scientist Development Three-Year Award, a jointly-sponsored fellowship in multiple sclerosis research, "to honor the contributions of Dr. Kurtzke and inspire new MS healthcare professionals to follow in his path."[13]

Like Klaus Lauer,[14] J. Kurtzke has dedicated a large part of his work to the study of MS in the Faroe Islands, with extensive studies dealing with the British occupation of the islands.,[15][16][17][18][19] starting what the New York Times called the MS "medical detective story".[20] He died on December 1, 2015.[21]

References

  1. ↑ "JOHN KURTZKE Obituary - Falls Church, VA - The Washington Post". The Washington Post. Retrieved 21 December 2015.
  2. ↑ Kurtzke JF (November 1983). "Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)". Neurology. 33 (11): 1444–52. doi:10.1212/WNL.33.11.1444. PMID 6685237.
  3. ↑ Kelley, Roger E.; Azizi, S. Ausim (September 2016). "Milton Alter, MD, PhD (1929–2016)". Neurology. 87 (10): 976–977. doi:10.1212/WNL.0000000000003074.
  4. ↑ http://www.direct-ms.org/pdf/GeneralInfoMS/CompstonStory.pdf%5Bfull+citation+needed%5D
  5. ↑ Kurtzke, John F. (1977). "Geography in multiple sclerosis". Journal of Neurology. 215 (1): 1–26. doi:10.1007/BF00312546. PMID 67196. Retrieved 21 December 2015.
  6. ↑ Kurtzke, John F. (1977). "Multiple sclerosis from an epidemiological viewpoint". In Field, E.J. Multiple Sclerosis: A Critical Conspectus. pp. 83–142. doi:10.1007/978-94-010-9534-1_4. ISBN 978-94-010-9536-5. Retrieved 21 December 2015.
  7. ↑ Owens GP, Bennett JL (2012). "Trigger, pathogen, or bystander: the complex nexus linking Epstein- Barr virus and multiple sclerosis". Mult. Scler. 18 (9): 1204–8. doi:10.1177/1352458512448109. PMC 5135482. PMID 22685062.
  8. ↑ Kurtzke, John F. (2006). "An epidemiologic view of the etiology of multiple sclerosis" (PDF). Archivos de Neurociencias. 11 (2): 90–99.
  9. ↑ http://www.va.gov/MS/Professionals/research/KurtzkeMonograph.pdf
  10. ↑ http://www.va.gov/MS/Professionals/research/Kurtzke_Slides.pdf
  11. ↑ http://rm2-msif-live.torchboxapps.com/en/research/msif_research_awards/the_charcot.html%5Bpermanent+dead+link%5D%5Bfull+citation+needed%5D
  12. ↑ http://www.nationalmssociety.org/ms-clinical-care-network/researchers/get-funding/john-dystel-prize/index.aspx%5Bfull+citation+needed%5D
  13. ↑ http://www.cmscfoundation.org/news2/press-releases/46-press-releases/125-new-multiple-sclerosis-fellowship-created-in-the-name-of-pioneer-neuroepidemiologist-john-f-kurtzke-md-faan%5Bfull+citation+needed%5D
  14. ↑ Lauer K (1988). "Multiple sclerosis in relation to industrial and commercial activities in the Faroe Islands". Neuroepidemiology. 7 (4): 228–33. doi:10.1159/000110155. PMID 3264057.
  15. ↑ Kurtzke JF, Hyllested K (January 1979). "Multiple sclerosis in the Faroe Islands: I. Clinical and epidemiological features". Annals of Neurology. 5 (1): 6–21. doi:10.1002/ana.410050104. PMID 371519.
  16. ↑ Kurtzke JF, Hyllested K (1988). "Validity of the epidemics of multiple sclerosis in the Faroe Islands". Neuroepidemiology. 7 (4): 190–227. doi:10.1159/000110154. PMID 3264056.
  17. ↑ Kurtzke, J. F.; Hyllested, K.; Heltberg, A.; Olsen, Á. (September 1993). "Multiple sclerosis in the Faroe Islands. 5". Acta Neurologica Scandinavica. 88 (3): 161–173. doi:10.1111/j.1600-0404.1993.tb04211.x. PMID 8256551. Retrieved 21 December 2015.
  18. ↑ Kurtzke, John F.; Hyllested, Kay (1992). "Multiple Sclerosis in the Faroe Islands and the Lack of Protection by Exposure in Infancy". Neuroepidemiology. 11 (2): 90–99. doi:10.1159/000110917. PMID 1495579.
  19. ↑ Kurtzke, John F.; Hyllested, Kay (March 1986). "Multiple sclerosis in the Faroe Islands". Neurology. 36 (3): 307–328. doi:10.1212/WNL.36.3.307. PMID 3951697. Retrieved 21 December 2015.
  20. ↑ Brody, Jane E. (22 June 1982). "MS: A Medical Detective Story". The New York Times. Retrieved 21 December 2015.
  21. ↑ "National MS Society Mourns the Passing of Dr. John Kurtzke". National Multiple Sclerosis Society. Archived from the original on 22 December 2015. Retrieved 21 December 2015.
  • Confavreux C (June 2012). "An unchanging man faced with changing times". Brain. 135 (Pt 6): 1663–5. doi:10.1093/brain/aws135. PMID 22628387.
  • Feigin V, Kurtzke JF, Korczyn A, Beghi E, Brown A (2009). "Bridging the gap between experimental and non-experimental neuroepidemiology, and ultimately - between neuroepidemiological research and practice: round table discussion at the First International Congress on Clinical Neurology and Epidemiology". Neuroepidemiology. 33 (4): 296–304. doi:10.1159/000252942. PMID 20443239.
  • Kurtzke JF, Hyllested K (January 1979). "Multiple sclerosis in the Faroe Islands: I. Clinical and epidemiological features". Annals of Neurology. 5 (1): 6–21. doi:10.1002/ana.410050104. PMID 371519.
  • portrait by E. Granieri. Once on page, press "look inside" icon
  • Kurtzke JF, Hyllested K, Arbuckle JD, et al. (December 1988). "Multiple sclerosis in the Faroe Islands. IV. The lack of a relationship between canine distemper and the epidemics of MS". Acta Neurologica Scandinavica. 78 (6): 484–500. doi:10.1111/j.1600-0404.1988.tb03692.x. PMID 3223236.
  • Audio podcast and transcript of interview by Consortium of MS centers
  • Kurtzke JF (December 2002). "No creative medical science without humor". Journal of Clinical Epidemiology. 55 (12): 1214–7. doi:10.1016/S0895-4356(02)00530-9. PMID 12547452.
  • Kurtzke JF (May 2005). "Epidemiology and etiology of multiple sclerosis". Physical Medicine and Rehabilitation Clinics of North America. 16 (2): 327–49. doi:10.1016/j.pmr.2005.01.013. PMID 15893675.
  • Kurtzke JF, Hyllested K, Heltberg A (May 1995). "Multiple sclerosis in the Faroe Islands: transmission across four epidemics". Acta Neurologica Scandinavica. 91 (5): 321–5. doi:10.1111/j.1600-0404.1995.tb07015.x. PMID 7639059.
  • One of the first papers of Kurtzke (1954)
  • Wallin MT, Culpepper WJ, Coffman P, et al. (June 2012). "The Gulf War era multiple sclerosis cohort: age and incidence rates by race, sex and service". Brain. 135 (Pt 6): 1778–85. doi:10.1093/brain/aws099. PMID 22628389.
  • Kurtzke JF (September 2013). "Epidemiology in multiple sclerosis: a pilgrim's progress". Brain. 136 (Pt 9): 2904–17. doi:10.1093/brain/awt220. PMID 23983034.
  • Börü UT, Taşdemir M, Güler N, et al. (2011). "Prevalence of multiple sclerosis: door-to-door survey in three rural areas of coastal Black Sea regions of Turkey". Neuroepidemiology. 37 (3–4): 231–5. doi:10.1159/000334316. PMID 22133733.
  • Kurtzke JF (May 2000). "Multiple sclerosis in time and space--geographic clues to cause". Journal of Neurovirology. 6 Suppl 2: S134–40. PMID 10871801.
  • Kurtzke JF (2011). "On the prevalence of multiple sclerosis in Serbia". Neuroepidemiology. 37 (2): 107–8. doi:10.1159/000331234. PMID 21921644.
  • Kurtzke JF, Hyllested K (1988). "Validity of the epidemics of multiple sclerosis in the Faroe Islands". Neuroepidemiology. 7 (4): 190–227. doi:10.1159/000110154. PMID 3264056.
  • Boström I, Callander M, Kurtzke JF, Landtblom AM (November 2009). "High prevalence of multiple sclerosis in the Swedish county of Värmland". Multiple Sclerosis (Houndmills, Basingstoke, England). 15 (11): 1253–62. doi:10.1177/1352458509345909. PMID 19805442.
  • Wallin MT, Page WF, Kurtzke JF (September 2009). "Migration and multiple sclerosis in Alaskan military veterans". Journal of Neurology. 256 (9): 1413–7. doi:10.1007/s00415-009-5123-5. PMID 19377862.
  • Cabrera-Gómez JA, Kurtzke JF, González-Quevedo A, Lara-Rodríguez R (January 2009). "An epidemiological study of neuromyelitis optica in Cuba". Journal of Neurology. 256 (1): 35–44. doi:10.1007/s00415-009-0009-0. PMID 19224310.
  • Kurtzke JF (October 1993). "Epidemiologic evidence for multiple sclerosis as an infection". Clinical Microbiology Reviews. 6 (4): 382–427. doi:10.1128/CMR.6.4.382. PMC 358295. PMID 8269393.
  • Kurtzke JF (2008). "Historical and clinical perspectives of the expanded disability status scale". Neuroepidemiology. 31 (1): 1–9. doi:10.1159/000136645. PMID 18535394.
  • Wallin MT, Page WF, Kurtzke JF (January 2004). "Multiple sclerosis in US veterans of the Vietnam era and later military service: race, sex, and geography". Annals of Neurology. 55 (1): 65–71. doi:10.1002/ana.10788. PMID 14705113.
  • Kurtzke JF, Heltberg A (January 2001). "Multiple sclerosis in the Faroe Islands: an epitome". Journal of Clinical Epidemiology. 54 (1): 1–22. doi:10.1016/S0895-4356(00)00268-7. PMID 11165464.
  • Rasmussen HB, Kvinesdal BB, Clausen J (July 1992). "Seroreactivity to human T cell leukemia/lymphoma virus type 1 and related retroviruses in multiple sclerosis patients from Denmark and the Faroes". Acta Neurologica Scandinavica. 86 (1): 91–4. doi:10.1111/j.1600-0404.1992.tb08061.x. PMID 1325731.
  • Kurtzke JF, Hyllested K (March 1986). "Multiple sclerosis in the Faroe Islands. II. Clinical update, transmission, and the nature of MS". Neurology. 36 (3): 307–28. doi:10.1212/wnl.36.3.307. PMID 3951697.
  • Kurtzke JF, Hyllested K (1978). "Multiple sclerosis in the Faroes: 1. Clinical and epidemiologic features". Transactions of the American Neurological Association. 103: 201–5. PMID 757058.
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