Jeannie T. Lee
Jeannie T. Lee | |
---|---|
Alma mater | Harvard University, University of Pennsylvania Medical School |
Awards |
2016 Lurie Award, 2016 Centennial Award from Genetics Society of America, 2015 election to National Academy of Sciences (NAS), 2010 Molecular Biology Award from NAS |
Scientific career | |
Fields | epigenetics, long noncoding RNA, X-inactivation |
Thesis | (1993) |
Doctoral advisor | Robert Nussbaum |
Jeannie T. Lee is a Professor of Genetics and Pathology at Harvard Medical School and the Massachusetts General Hospital, and a Howard Hughes Medical Institute Investigator. She is known for her work on X-chromosome inactivation and for discovering the functions of a new class of epigenetic regulators known as long noncoding RNAs (lncRNAs) for example Xist and Tsix.
Education
Jeannie T. Lee received an AB from Harvard College in Biochemistry & Molecular Biology and an MD/PhD in 1993[1] from the University of Pennsylvania School of Medicine.[2] While at University of Pennsylvania School of Medicine her advisor was Robert L. Nussbaum.[3] Her PhD research focused on Fragile X syndrome, and let to her strong interest in X chromosome inactivation and epigenetics.[4] Then she did postdoctoral work with Rudolf Jaenisch at the Whitehead Institute , during which she discovered the nature of the X-inactivation center.[3]
Research Career
Lee joined the faculty at Harvard in 1997 and devoted her studies to sex chromosome dynamics during development and disease. Her major career research achievements include identifying the X inactivation center,[5][6] discovering Tsix antisense RNA,[7] determining Xist's mechanism of action,[8][9] and demonstrating that a lncRNA is a regulator of Polycomb repressive complex 2.[10][11][12][13]
Her studies established the existence and function of a group of regulatory RNAs known as long noncoding RNAs or lncRNAs. There are about ten times as many lncRNAs in a eukaryotic cell as mRNAs. In a 2013 interview, she was asked what excited her about this group of RNAs. She said they control gene expression in a locus-specific way, by recruiting chromatin modifying activities to the locus, so the lncRNAs make excellent drug design targets. She founded RaNA Therapeutics to test this idea. [3]
Upon conferring the Lurie Prize to Lee in 2016, Dr. Charles A. Sanders of the Foundation for the National Institutes of Health remarked: “Dr. Lee’s work has revolutionized the field of epigenetics. Her research has led to groundbreaking contributions, and we now have a better understanding of the unique role that long non-coding RNAs play in gene expression, which could lead to the development of new therapeutics.”[14]
She is the 2018 President of the Genetics Society of America.[15]
Awards
- 2000 Pew Scholar[16]
- 1998 Basil O'Connor Scholar Award
- 2011 NIH MERIT Award
- 2010 Elected Fellow of the American Association for the Advancement of Science (AAAS)
- 2010 Molecular Biology Award from the National Academy of Sciences
- 2014 Distinguished Graduate Award of the University of Pennsylvania Perelman School of Medicine
- 2015 Elected member of the National Academy of Sciences[17]
- 2016 Centennial Award from GENETICS, Genetics Society of America[18]
- 2016 Lurie Prize in Biomedical Sciences from the Foundation for the National Institutes of Health
References
- ↑ "Jeannie T. Lee". Massachusetts General Hospital. Retrieved August 15, 2018.
- ↑ http://www.hhmi.org/scientists/jeannie-t-lee
- 1 2 3 "Interview with Jeannie T. Lee". Oligonucleotide Therapeutics Society. August 13, 2016.
- ↑ Viegas, J. "QnAs with Jeannie T. Lee". Proc Natl Acad Sci U S A. 112: 14745–6. doi:10.1073/pnas.1521185112. PMC 4672782. PMID 26582793.
- ↑ Lee, J. T.; Strauss, W. M.; Dausman, J. A.; Jaenisch, R. (1996-07-12). "A 450 kb transgene displays properties of the mammalian X-inactivation center". Cell. 86 (1): 83–94. ISSN 0092-8674. PMID 8689690.
- ↑ Lee, J. T.; Lu, N.; Han, Y. (1999-03-30). "Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3836–3841. ISSN 0027-8424. PMID 10097124.
- ↑ Lee, J. T.; Davidow, L. S.; Warshawsky, D. (April 1999). "Tsix, a gene antisense to Xist at the X-inactivation centre". Nature Genetics. 21 (4): 400–404. doi:10.1038/7734. ISSN 1061-4036. PMID 10192391.
- ↑ Zhao, Jing; Sun, Bryan K.; Erwin, Jennifer A.; Song, Ji-Joon; Lee, Jeannie T. (2008-10-31). "Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome". Science. 322 (5902): 750–756. doi:10.1126/science.1163045. ISSN 1095-9203. PMC 2748911. PMID 18974356.
- ↑ Minajigi, Anand; Froberg, John; Wei, Chunyao; Sunwoo, Hongjae; Kesner, Barry; Colognori, David; Lessing, Derek; Payer, Bernhard; Boukhali, Myriam (2015-07-17). "A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation". Science. 349 (6245). doi:10.1126/science.aab2276. ISSN 0036-8075. PMC 4845908. PMID 26089354.
- ↑ Zhao, Jing; Sun, Bryan K.; Erwin, Jennifer A.; Song, Ji-Joon; Lee, Jeannie T. (2008-10-31). "Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome". Science. 322 (5902): 750–756. doi:10.1126/science.1163045. ISSN 1095-9203. PMC 2748911. PMID 18974356.
- ↑ Zhao, Jing; Ohsumi, Toshiro K.; Kung, Johnny T.; Ogawa, Yuya; Grau, Daniel J.; Sarma, Kavitha; Song, Ji Joon; Kingston, Robert E.; Borowsky, Mark (2010-12-22). "Genome-wide identification of polycomb-associated RNAs by RIP-seq". Molecular Cell. 40 (6): 939–953. doi:10.1016/j.molcel.2010.12.011. ISSN 1097-4164. PMC 3021903. PMID 21172659.
- ↑ Cifuentes-Rojas, Catherine; Hernandez, Alfredo J.; Sarma, Kavitha; Lee, Jeannie T. (2014-07-17). "Regulatory interactions between RNA and polycomb repressive complex 2". Molecular Cell. 55 (2): 171–185. doi:10.1016/j.molcel.2014.05.009. ISSN 1097-4164. PMC 4107928. PMID 24882207.
- ↑ Zovoilis, Athanasios; Cifuentes-Rojas, Catherine; Chu, Hsueh-Ping; Hernandez, Alfredo J.; Lee, Jeannie T. (2016-12-15). "Destabilization of B2 RNA by EZH2 Activates the Stress Response". Cell. 167 (7): 1788–1802.e13. doi:10.1016/j.cell.2016.11.041. ISSN 1097-4172. PMC 5552366. PMID 27984727.
- ↑ "Foundation for the NIH to Award Lurie Prize in Biomedical Sciences to Dr. Jeannie Lee for Pioneering Work in Epigenetics | FNIH". fnih.org. Retrieved 2017-09-30.
- ↑ http://www.nasonline.org/member-directory/members/20033180.html
- ↑ http://www.oligotherapeutics.org/interview-with-jeannie-t-lee-md-phd/
- ↑ http://www.nasonline.org/member-directory/members/20033180.html
- ↑ "Centennial Awards honor outstanding GENETICS articles". EurekAlert!. Retrieved 2017-09-30.