JAG2

JAG2
Identifiers
AliasesJAG2, HJ2, SER2, jagged 2
External IDsMGI: 1098270 HomoloGene: 1677 GeneCards: JAG2
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.33Start105,140,981 bp[1]
End105,168,824 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3714

16450

Ensembl

ENSG00000184916

ENSMUSG00000002799

UniProt

Q9Y219

Q9QYE5

RefSeq (mRNA)

NM_002226
NM_145159

NM_010588

RefSeq (protein)

NP_002217
NP_660142

NP_034718

Location (UCSC)Chr 14: 105.14 – 105.17 MbChr 12: 112.91 – 112.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Jagged-2 is a protein that in humans is encoded by the JAG2 gene.[5][6][7]

Function

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

JAG2 has been shown to interact with NOTCH2.[8]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184916 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002799 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol. 17 (10): 6057–67. PMC 232455. PMID 9315665.
  6. ↑ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.
  7. 1 2 "Entrez Gene: JAG2 jagged 2".
  8. ↑ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
  9. ↑ Wang; Remke; Bhat; Wong; Zhou; Ramaswamy; Dubuc; Fonkem; Salem; Zhang; Hsieh; O'Rourke; Wu; Li; Hawkins; Kohane; Wu; Wu; Taylor (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma". Oncotarget. 6: 2709–24. doi:10.18632/oncotarget.2779. PMC 4413612. PMID 25576913.

Further reading

  • Shawber C, Boulter J, Lindsell CE, Weinmaster G (1997). "Jagged2: a serrate-like gene expressed during rat embryogenesis". Dev. Biol. 180 (1): 370–6. doi:10.1006/dbio.1996.0310. PMID 8948600.
  • Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI (1998). "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions". Mech. Dev. 69 (1–2): 203–7. doi:10.1016/S0925-4773(97)00146-9. PMID 9486542.
  • Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
  • Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW (1999). "Notch signalling pathway mediates hair cell development in mammalian cochlea". Nat. Genet. 21 (3): 289–92. doi:10.1038/6804. PMID 10080181.
  • Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I (1999). "Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development". Int. Immunol. 11 (7): 1017–25. doi:10.1093/intimm/11.7.1017. PMID 10383933.
  • Tsai S, Fero J, Bartelmez S (2000). "Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood. 96 (3): 950–7. PMID 10910909.
  • Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
  • Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
  • Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. Physiol. 185 (3): 425–31. doi:10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U. PMID 11056013.
  • Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L (2001). "Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction". Am. J. Pathol. 159 (3): 875–83. doi:10.1016/S0002-9440(10)61763-4. PMC 1850458. PMID 11549580.
  • Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H (2002). "Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes". J. Androl. 22 (6): 999–1011. PMID 11700865.
  • Ikeuchi T, Sisodia SS (2003). "The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200. PMID 12551931.
  • Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ (2004). "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood. 104 (12): 3697–704. doi:10.1182/blood-2003-12-4114. PMID 15292061.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Yao Y, Yao J, Radparvar M, Blazquez-Medela AM, Guihard PJ, Jumabay M, Boström KI (2013). "Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency". Proc. Natl. Acad. Sci. U.S.A. 110 (47): 19071–6. doi:10.1073/pnas.1310905110. PMC 3839731. PMID 24191040.


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