Iva Tolić

Prof. dr. sc.
Iva Tolić
Iva Tolić, Ruđer Bošković Institute
Born (1974-06-24) June 24, 1974
Zagreb, Croatia
Nationality Croatian
Occupation Scientist/Academic
Spouse(s) Nenad Brgić (married 2014)
Children 2
Awards Croatian Women of Influence Award 2016, EBSA Young Investigators' Medal and Prize 2015, Order of the Danica Hvratska for science, European Life Science Investigator of the Year Award 2014, Cell '40 under 40' 2014
Academic background
Education PhD
Alma mater University of Zagreb, Croatia
Thesis  (2002)
Academic work
Discipline Biology
Sub-discipline Biophysics
Institutions Max Planck Institute of Molecular Cell Biology and Genetics (Dresden, Germany)
Ruđer Bošković Institute
(Zagreb, Croatia)
Website http://tolic.irb.hr/

Iva Marija Tolić (born 24 June 1974) is a Croatian biophysicist, known for her work on the microtubule cytoskeleton and associated motor proteins. She is currently Senior Research Group Leader and Professor of Biology at the Ruđer Bošković Institute in Zagreb, Croatia.[1]

Education

Tolić completed her Diploma in Molecular Biology from the University of Zagreb, Croatia in 1996 and her Graduate Studies in Molecular Biology in the group of Prof. Nenad Trinajstić, Ruđer Bošković Institute and University of Zagreb, Croatia in 1999. Between 1999 and 2001, she completed part of her PhD work with Prof. Ning Wang, Harvard School of Public Health, Boston, United States and was awarded her doctorate in Biology in 2002 by the University of Zagreb, Croatia.[1]

Career

Upon obtaining her doctorate, Tolić did her first Post-doctoral training between 2001 and 2002 at the Niels Bohr Institute, Copenhagen, Denmark working with Prof. Lene Oddershede and Prof. Kirstine Berg-Sorensen on the microrheology of cells. She then joined the European Laboratory for Non-Linear Spectroscopy, Florence, Italy for post-doctoral research with Prof. Francesco Pavone, working on lymphocyte movement and laser microsurgery on the mitotic spindle. Following her Post-doctoral training, Tolić was appointed as Research Group Leader (W1, equivalent to Assistant Professor) at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany in 2005 and was promoted to Senior Research Group Leader (W2, equivalent to Associate Professor) in 2010. In 2014, she moved to the Ruđer Bošković Institute, Zagreb, Croatia, being appointed as Senior Research Group Leader and Professor of Biology.[2] Under her mentorship, 6 PhDs, 4 master's degrees and 6 diplomas have been awarded.

Research

As independent investigator, Tolić has carried out pioneering research in the field of cell biology pertaining to the microtubule cytoskeleton and associated motor proteins, discovering: (i) a novel mechanism of kinetochore capture during mitosis by pivoting of astral microtubules around the spindle pole,[3] (ii) a mechanism of regulation of the motor protein cytoplasmic dynein by attachment to its anchor protein in fission yeast[4] and most recently, (iii) 'Bridging fibers' that are non-kinetochore microtubules connecting sister k-fibers and thereby balancing forces in the spindle.[5]

In addition, her research has demonstrated that fission yeast does not undergo replicative aging, contrary to existing theories on aging.[6][7]

Personal life

Tolić's parents are the journalist and diplomat Benjamin Tolić and academic Dubravka Oraić-Tolić. She married Nenad Brgić in 2014 and she is the mother of two children. She has stated publicly that she sees no conflict between religion and science.[8]

Awards and Achievements

  • Croatian Women of Influence Award, 2016.[9]
  • Special award of the Ruđer Bošković Institute for outstanding contribution to the scientific excellence and international recognition of the institute, 2015.
  • European Biophysical Societies Association Young Investigators' Medal and Prize, 2015.[10]
  • 5000th Grantee of the European Research Council, 2015.[11]
  • MRAK award for creativity in science awarded for the collaboration with the Ruđer Bošković Institute.
  • Order of Danica Hrvatska for science, outstanding contributions to science and its promotion in the Republic of Croatia and the world, 2014
  • Investigator of the Year, European Life Science Award, 2014.[12]
  • Featured on Cell "40 under 40", 2014.[13]

Membership in Professional Associations and Societies

Tolić is a member of the Croatian Biophysical Society, the Croatian Society of Biochemistry and Molecular Biology and the Croatian Microscopy Society. In addition, she is Member of the Scientific Advisory Board of the journal Science journal.

Publications

Tolić has 65 publications in international peer-reviewed journals to her credit, with a total citation count of ~3500 and an h-index of 26.

Media Coverage

Tolić and her research have been covered by several international and Croatian media outlets: Gloria, Croatia Airlines, Bild and Voice of Croatia, to name a few.[14]

References

  1. 1 2 RBI. "Iva Tolić / People / Ruđer Bošković Institute". www.irb.hr.
  2. ↑
  3. ↑ Kalinina, Iana; Nandi, Amitabha; Delivani, Petrina; Chacón, Mariola R.; Klemm, Anna H.; Ramunno-Johnson, Damien; Krull, Alexander; Lindner, Benjamin; Pavin, Nenad; Tolić-Nørrelykke, Iva M. (2012). "Pivoting of microtubules around the spindle pole accelerates kinetochore capture". Nature Cell Biology. 15 (1): 82–87. doi:10.1038/ncb2640. ISSN 1465-7392.
  4. ↑ Ananthanarayanan, Vaishnavi; Schattat, Martin; Vogel, Sven K.; Krull, Alexander; Pavin, Nenad; Tolić-Nørrelykke, Iva M. (2013). "Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring". Cell. 153 (7): 1526–1536. doi:10.1016/j.cell.2013.05.020. ISSN 0092-8674. PMID 23791180.
  5. ↑ Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva M. (2016). "Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores". Nature Communications. 7: 10298. doi:10.1038/ncomms10298. ISSN 2041-1723. PMC 4728446. PMID 26728792.
  6. ↑ Coelho, Miguel; Dereli, Aygül; Haese, Anett; Kühn, Sebastian; Malinovska, Liliana; DeSantis, Morgan E.; Shorter, James; Alberti, Simon; Gross, Thilo; Tolić-Nørrelykke, Iva M. (2013). "Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress". Current Biology. 23 (19): 1844–1852. doi:10.1016/j.cub.2013.07.084. ISSN 0960-9822. PMC 4620659. PMID 24035542.
  7. ↑ Coelho, Miguel; Lade, Steven J.; Alberti, Simon; Gross, Thilo; Tolić, Iva M. (2014). "Fusion of Protein Aggregates Facilitates Asymmetric Damage Segregation". PLoS Biology. 12 (6): e1001886. doi:10.1371/journal.pbio.1001886. ISSN 1545-7885. PMC 4061010. PMID 24936793.
  8. ↑ S, Veronika. "Prof. dr. Iva Tolić, hrvatska znanstvenica uvrštena među 40 najboljih u svijetu". Kamenjar. Retrieved 31 December 2017.
  9. ↑
  10. ↑ "Prizes and medals awarded by EBSA - European Biophysical Societies' Association". ebsa.org.
  11. ↑
  12. ↑ "Investigator of the Year". mpi-cbg.de.
  13. ↑ "Iva Tolic-Norrelykke: Cell Press". www.cell.com.
  14. ↑ "Media Coverage - Iva Tolić Group". tolic.irb.hr.
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