Itaconyl-CoA hydratase
| itaconyl-CoA hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.56 | ||||||||
| CAS number | 37290-83-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an itaconyl-CoA hydratase (EC 4.2.1.56) is an enzyme that catalyzes the chemical reaction
- citramalyl-CoA itaconyl-CoA + H2O
Hence, this enzyme has one substrate, citramalyl-CoA, and two products, itaconyl-CoA and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is citramalyl-CoA hydro-lyase (itaconyl-CoA-forming). Other names in common use include itaconyl coenzyme A hydratase, and citramalyl-CoA hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism.
References
- Cooper RA, Kornberg HL (1964). "The utilization of itaconate by Pseudomonas sp". Biochem. J. 91 (1): 82&ndash, 91. PMC 1202819. PMID 4284209.
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