IsrM small RNA

IsrM sRNA
Predicted secondary structure and sequence conservation of IsrM small RNA
Identifiers
Rfam RF02763
Other data
Domain(s) Bacteria
GO 0009405,0040033
SO 0000370
PDB structures PDBe


The IsrM RNA is a small non-coding RNA discovered in Salmonella pathogenicity island, which is not found in E.coli.[1] It is important for invasion of epithelial cells, intracellular replication inside macrophages, virulence and colonisation in mice. It targets the SopA and HilE mRNAs, virulence factors essential for bacterial invasion. It is a first pathogenicity island-encoded sRNA shown to be directly involved in Salmonella pathogenesis.[2]

References

  1. ↑ Padalon-Brauch, Gilly; Hershberg, Ruth; Elgrably-Weiss, Maya; Baruch, Kobi; Rosenshine, Ilan; Margalit, Hanah; Altuvia, Shoshy (2008-04-01). "Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence". Nucleic Acids Research. 36 (6): 1913–1927. doi:10.1093/nar/gkn050. ISSN 1362-4962. PMC 2330248. PMID 18267966.
  2. ↑ Gong, Hao; Vu, Gia-Phong; Bai, Yong; Chan, Elton; Wu, Ruobin; Yang, Edward; Liu, Fenyong; Lu, Sangwei (2011-09-01). "A Salmonella small non-coding RNA facilitates bacterial invasion and intracellular replication by modulating the expression of virulence factors". PLOS Pathogens. 7 (9): e1002120. doi:10.1371/journal.ppat.1002120. ISSN 1553-7374. PMC 3174252. PMID 21949647.


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