Ionomycin
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IUPAC name
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-Dihydroxy-22-{(2S,2′R,5S,5′S)-5′-[(1R)-1-hydroxyethyl]-2,5′-dimethyloctahydro-2,2′-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoic acid | |
Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.121.228 |
PubChem CID |
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Properties | |
C41H72O9 | |
Molar mass | 709.0050 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus.[1] It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. It is also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. These cytokines are important in the inflammatory response.
Commercially, Ionomycin can be obtained as a free acid, or as a Ca2+ salt.
References
- ↑ See Ionomycin Calcium salt Archived 2006-06-26 at the Wayback Machine. from Fermentek, manufacturer's product page for ionomycin
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