Intracellular pH

Intracellular pH (pHi) is the measure of the acidity or basicity (i.e., pH) of intracellular fluid. The pHi plays a critical role in membrane transport and other intracellular processes. The mechanisms that regulate pHi are usually considered to be plasma membrane transporters of which two main types exist — those that are dependent and those that are independent of HCO3−. Physiologically normal intracellular pH is most commonly between 7.0 and 7.4, though there is variability between tissues (e.g., mammalian skeletal muscle tends to have a pHi of 6.8-7.1).[1][2][3]

Intracellular pH is typically lower than extracellular pH due to lower concentrations of HCO3− . When extracellular (e.g., serum) pCO2 levels rise above 45 mmHg, the cell will uptake more H+ to buffer, and pHi decreases.

Lymphocytes maintain a constant internal pH of 7.17± 0.06, though, like all cells, the intracellular pH changes in the same direction as extracellular pH.[4]

Pioneer researchers in the area of intracellular pH include Jacques Pouyssegur (University of Nice, France), Albrecht Schwab, University of Münster, Germany, and Diane Barber, University of California, San Francisco, USA.

References

  1. ↑ "UpToDate". www.uptodate.com.
  2. ↑ "2.6 Regulation of Intracellular Hydrogen Ion Concentration". www.anaesthesiamcq.com. Retrieved 2018-10-06.
  3. ↑ Madshus, Inger Helene (1988). "Review article - Regulation of intracellular pH in eukaryotic cells" (PDF). Biochem. J. 250: 1–8.
  4. ↑ C. Deutsch; J. S. Taylor; D. F. Wilson (December 1982). "Regulation of intracellular pH by human peripheral blood lymphocytes as measured by 19F NMR" (PDF). Proc. Natl. Acad. Sci. U.S.A. 79 (24): 7944–7948. doi:10.1073/pnas.79.24.7944. PMC 347466. PMID 6961462. Retrieved 2014-08-01.


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