IWS1

IWS1
Identifiers
AliasesIWS1, SUPT6H interacting protein
External IDsMGI: 1920723 HomoloGene: 134421 GeneCards: IWS1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.3Start127,436,207 bp[1]
End127,526,886 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55677

73473

Ensembl

ENSG00000163166

ENSMUSG00000024384

UniProt

Q96ST2

Q8C1D8

RefSeq (mRNA)

NM_017969

NM_173441

RefSeq (protein)

NP_060439

NP_775617

Location (UCSC)Chr 2: 127.44 – 127.53 MbChr 18: 32.07 – 32.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.[5]

IWS1 an transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.[6] The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival.[7] It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163166 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024384 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: IWS1 IWS1 homolog (S. cerevisiae)".
  6. ↑ Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF (Oct 2002). "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach". Molecular and Cellular Biology. 22 (20): 6979–92. doi:10.1128/MCB.22.20.6979-6992.2002. PMC 139818. PMID 12242279.
  7. ↑ Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735.
  8. ↑ Yoh SM, Lucas JS, Jones KA (Dec 2008). "The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation". Genes & Development. 22 (24): 3422–34. doi:10.1101/gad.1720008. PMC 2607075. PMID 19141475.

Further reading

  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Ling Y, Smith AJ, Morgan GT (2006). "A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS". Nucleic Acids Research. 34 (8): 2219–29. doi:10.1093/nar/gkl239. PMC 1450333. PMID 16648364.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735.
  • Yoh SM, Cho H, Pickle L, Evans RM, Jones KA (Jan 2007). "The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export". Genes & Development. 21 (2): 160–74. doi:10.1101/gad.1503107. PMC 1770899. PMID 17234882.


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