ITPKB

ITPKB
Identifiers
Aliases	ITPKB, IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37, inositol-trisphosphate 3-kinase B
External IDs	MGI: 109235 HomoloGene: 1672 GeneCards: ITPKB
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	226,739,323 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	180,424,802 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • calmodulin binding; • kinase activity; • protein binding; • ATP binding; • inositol-1,4,5-trisphosphate 3-kinase activity;
Cellular component	• cytosol; • membrane; • cell nucleus;
Biological process	• regulation of protein phosphorylation; • cellular response to calcium ion; • negative regulation of neutrophil apoptotic process; • phosphorylation; • common myeloid progenitor cell proliferation; • myeloid cell homeostasis; • positive regulation of Ras protein signal transduction; • inositol phosphate metabolic process; • inositol trisphosphate metabolic process; • MAPK cascade; • cell surface receptor signaling pathway; • T cell differentiation; • positive thymic T cell selection; • negative regulation of myeloid cell differentiation; • positive regulation of alpha-beta T cell differentiation; • thymic T cell selection; • signal transduction; • inositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3707
	320404
	ENSG00000143772
	ENSMUSG00000038855
	P27987
	B2RXC2
	NM_002221
	NM_001081175
	NP_002212
	NP_001074644
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.^[5]^[6]

Function

The protein encoded by this gene regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.^[7] Itpkb regulates immune cell function and is required for T and B cell development.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143772 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038855 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Takazawa K, Perret J, Dumont JE, Erneux C (Oct 1991). "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme". Biochem J. 278 (3): 883–6. PMC 1151429. PMID 1654894.
↑ Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (Dec 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics. 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.
↑ "Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B".
↑ Sauer K, Cooke MP (April 2010). "Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate". Nat. Rev. Immunol. 10 (4): 257–71. doi:10.1038/nri2745. PMC 2922113. PMID 20336153.

ITPKB

Function

References

Further reading