Integrin alpha 8

ITGA8
Identifiers
Aliases	ITGA8, integrin subunit alpha 8
External IDs	MGI: 109442 HomoloGene: 37396 GeneCards: ITGA8
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	15,720,125 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	12,301,922 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• metal ion binding;
Cellular component	• integral component of membrane; • perikaryon; • membrane; • postsynaptic density; • focal adhesion; • integrin alpha8-beta1 complex; • plasma membrane; • apical part of cell; • cell surface; • integrin complex; • endoplasmic reticulum; • dendritic spine membrane;
Biological process	• positive regulation of transforming growth factor beta receptor signaling pathway; • cell differentiation; • kidney development; • establishment of protein localization; • extracellular matrix organization; • memory; • nervous system development; • multicellular organism development; • brain development; • cell adhesion; • cell projection organization; • inner ear morphogenesis; • positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; • smooth muscle tissue development; • mesodermal cell differentiation; • integrin-mediated signaling pathway; • substrate adhesion-dependent cell spreading; • cell-matrix adhesion; • metanephros development; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	8516
	241226
	ENSG00000077943
	ENSMUSG00000026768
	P53708
	A2ARA8
	NM_001291494; NM_003638
	NM_001001309
	NP_001278423; NP_003629
	NP_001001309
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077943 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026768 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. PMID 7768999.
↑ "Entrez Gene: ITGA8 integrin, alpha 8".

Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C". Biochemistry. 37 (16): 5464–74. doi:10.1021/bi9727489. PMC 2710129. PMID 9548928.
Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111.
Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney". J. Cell Biol. 154 (2): 447–58. doi:10.1083/jcb.200103069. PMC 2150762. PMID 11470831.
Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102. PMID 11668187.
Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. doi:10.1073/pnas.122229199. PMC 123025. PMID 12060755.
Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1". J. Cell Sci. 115 (Pt 23): 4641–8. doi:10.1242/jcs.00145. PMID 12415008.
Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro". Oncogene. 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.

External links

ITGA8 Info with links in the Cell Migration Gateway

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077943 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026768 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid7768999-5] Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. PMID 7768999.

[entrez-6] "Entrez Gene: ITGA8 integrin, alpha 8".

Integrin alpha 8

References

Further reading

External links