INSL5

INSL5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINSL5, PRO182, UNQ156, insulin like 5
External IDsMGI: 1346085 HomoloGene: 48350 GeneCards: INSL5
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p31.3Start66,797,741 bp[1]
End66,801,256 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10022

23919

Ensembl

ENSG00000172410

ENSMUSG00000066090

UniProt

Q9Y5Q6

Q9WUG6

RefSeq (mRNA)

NM_005478

NM_001290648
NM_011831

RefSeq (protein)

NP_005469

NP_001277577
NP_035961

Location (UCSC)Chr 1: 66.8 – 66.8 MbChr 4: 103.02 – 103.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin-like peptide INSL5 is a protein that in humans is encoded by the INSL5 gene.[5][6]

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7).[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172410 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066090 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S, Jaspers S (August 1999). "Identification of INSL5, a new member of the insulin superfamily". Genomics. 60 (1): 50–6. doi:10.1006/geno.1999.5899. PMID 10458910.
  6. 1 2 "Entrez Gene: INSL5 insulin-like 5".

Further reading

  • Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639.
  • Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Koman A, Cazaubon S, Couraud PO, Ullrich A, Strosberg AD (August 1996). "Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family". The Journal of Biological Chemistry. 271 (34): 20238–41. doi:10.1074/jbc.271.34.20238. PMID 8702754.
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