INPP5B

INPP5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MTC, 3N9V, 4CML, 5A7J, 5A7I
Identifiers
Aliases	INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs	MGI: 103257 HomoloGene: 69021 GeneCards: INPP5B
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	37,947,057 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	124,801,511 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• metal ion binding; • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; • protein binding; • hydrolase activity; • GTPase activator activity; • inositol-1,4,5-trisphosphate 5-phosphatase activity; • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; • inositol phosphate phosphatase activity;
Cellular component	• integral component of membrane; • cytosol; • endosome; • phagocytic vesicle membrane; • Golgi apparatus; • early endosome membrane; • membrane; • plasma membrane; • cytoplasmic vesicle; • endoplasmic reticulum-Golgi intermediate compartment; • cytoplasm;
Biological process	• flagellated sperm motility; • in utero embryonic development; • inositol phosphate metabolic process; • regulation of protein processing; • phosphatidylinositol dephosphorylation; • spermatogenesis; • regulation of small GTPase mediated signal transduction; • signal transduction; • positive regulation of GTPase activity; • inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3633
	16330
	ENSG00000204084
	ENSMUSG00000028894
	P32019
	Q8K337
	NM_001297434; NM_005540; NM_001350227; NM_001350228
	NM_008385
	NP_001284363; NP_005531; NP_001337156; NP_001337157
	NP_032411
	Wikidata
View/Edit Human	View/Edit Mouse

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.^[5]^[6]

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204084 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028894 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. PMID 1718960.
1 2 "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets". J. Biol. Chem. 264 (15): 8873–7. PMID 2542294.
Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase". J. Biol. Chem. 270 (16): 9370–7. doi:10.1074/jbc.270.16.9370. PMID 7721860.
Jänne PA, Dutra AS, Dracopoli NC, et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34". Cytogenet. Cell Genet. 66 (3): 164–6. doi:10.1159/000133691. PMID 8125013.
Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase". Eur. J. Biochem. 234 (1): 216–24. doi:10.1111/j.1432-1033.1995.216_c.x. PMID 8529643.
Jänne PA, Rochelle JM, Martin-DeLeon PA, et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens". Genomics. 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000204084 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028894 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid1718960-5] Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. PMID 1718960.

[entrez-6] 1 2 "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

INPP5B

References

Further reading