ILKAP

ILKAP
Identifiers
AliasesILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase
External IDsMGI: 1914694 HomoloGene: 31525 GeneCards: ILKAP
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q37.3Start238,170,401 bp[1]
End238,203,729 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80895

67444

Ensembl

ENSG00000132323

ENSMUSG00000026309

UniProt

Q9H0C8

Q8R0F6

RefSeq (mRNA)

NM_030768
NM_176799

NM_023343
NM_001355152

RefSeq (protein)

NP_110395

NP_075832
NP_001342081

Location (UCSC)Chr 2: 238.17 – 238.2 MbChr 1: 91.37 – 91.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[5]

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[5]

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132323 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026309 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
  6. ↑ Leung-Hagesteijn, C; Mahendra A; Naruszewicz I; Hannigan G E (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. England. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. ISSN 0261-4189. PMC 125446. PMID 11331582.

Further reading

  • Tong Y, Quirion R, Shen SH (1999). "Cloning and characterization of a novel mammalian PP2C isozyme". J. Biol. Chem. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kumar AS, Naruszewicz I, Wang P, et al. (2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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