IK (gene)

IK
Identifiers
Aliases	IK, CSA2, RED, IK cytokine, down-regulator of HLA II, RER, IK cytokine
External IDs	MGI: 1345142 HomoloGene: 36193 GeneCards: IK
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	140,662,479 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	36,757,639 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein binding; • identical protein binding;
Cellular component	• nuclear speck; • nuclear chromosome; • mitotic spindle pole; • spindle pole; • nucleoplasm; • spliceosomal complex; • chromosome; • cytoplasm; • cytoskeleton; • cell nucleus; • U2-type precatalytic spliceosome;
Biological process	• mitotic cell cycle; • mitotic spindle assembly checkpoint; • protein localization to kinetochore; • mRNA processing; • RNA splicing; • viral process; • mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	3550
	24010
	ENSG00000113141
	ENSMUSG00000024474
	Q13123; Q95HA6
	Q9Z1M8
	NM_006083
	NM_011879
	NP_006074; NP_006074.2
	NP_036009
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Red is a protein that in humans is encoded by the IK gene.^[5]^[6]

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID 7970704.
1 2 "Entrez Gene: IK IK cytokine, down-regulator of HLA II".

Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation". Blood. 89 (10): 3615–23. PMID 9160666.
Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat". Gene. 230 (2): 145–54. doi:10.1016/S0378-1119(99)00066-9. PMID 10216252.
Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation". J. Invest. Dermatol. 116 (6): 874–9. doi:10.1046/j.1523-1747.2001.01339.x. PMID 11407974.

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