IFT57

IFT57
Identifiers
Aliases	IFT57, ESRRBL1, HIPPI, MHS4R2, intraflagellar transport 57, OFD18
External IDs	MGI: 1921166 HomoloGene: 32383 GeneCards: IFT57
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	108,222,570 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	49,765,126 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • protein binding;
Cellular component	• intraciliary transport particle B; • cytoplasm; • ciliary basal body; • centrosome; • Golgi apparatus; • cell projection; • photoreceptor connecting cilium; • dendrite terminus; • ciliary tip; • axoneme; • cytoskeleton; • cilium;
Biological process	• regulation of apoptotic process; • regulation of transcription, DNA-templated; • intraciliary transport; • transcription, DNA-templated; • heart looping; • neural tube closure; • negative regulation of epithelial cell proliferation; • smoothened signaling pathway; • left/right pattern formation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • apoptotic process; • intraciliary transport involved in cilium assembly; • motile cilium assembly; • non-motile cilium assembly; • cilium morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55081
	73916
	ENSG00000114446
	ENSMUSG00000032965
	Q9NWB7
	Q8BXG3
	NM_018010
	NM_028680
	NP_060480
	NP_082956
	Wikidata
View/Edit Human	View/Edit Mouse

Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.^[5]

Interactions

IFT57 has been shown to interact with Caspase 8.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114446 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032965 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas)".
↑ Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820.
Mattson MP (2002). "Accomplices to neuronal death". Nature. 415 (6870): 377–9. doi:10.1038/415377a. PMID 11807533.
Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY (2003). "The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1". Biochem. Biophys. Res. Commun. 305 (2): 359–64. doi:10.1016/S0006-291X(03)00764-2. PMID 12745083.
Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC (2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia". J. Biol. Chem. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nat. Genet. 36 (9): 989–93. doi:10.1038/ng1414. PMID 15314642.
Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP (2006). "Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1". Neurobiol. Dis. 22 (2): 242–56. doi:10.1016/j.nbd.2005.11.003. PMID 16364650.
Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U (2006). "Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1". Acta Crystallographica Section F. 62 (Pt 12): 1247–50. doi:10.1107/S1744309106046628. PMC 2225382. PMID 17142908.
Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP (2007). "Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo". Biochem. Biophys. Res. Commun. 353 (1): 80–5. doi:10.1016/j.bbrc.2006.11.138. PMID 17173859.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114446 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032965 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas)".

[pmid11788820-6] Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820.

IFT57

Interactions

References

Further reading