IFIT2

IFIT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2
External IDsMGI: 99449 HomoloGene: 1187 GeneCards: IFIT2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q23.31Start89,283,694 bp[1]
End89,309,276 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3433

15958

Ensembl

ENSG00000119922

ENSMUSG00000045932

UniProt

P09913

Q64112

RefSeq (mRNA)

NM_001547

NM_008332
NM_001355262

RefSeq (protein)

NP_001538

NP_032358
NP_001342191

Location (UCSC)Chr 10: 89.28 – 89.31 MbChr 19: 34.55 – 34.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 is a protein found in humans which is encoded by the IFIT2 gene.[5][6][7]

Clinical significance

IFIT2 may play a role in prevention of tumor progression.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119922 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045932 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763.
  6. ↑ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. doi:10.1016/0014-5793(88)80724-5. PMID 3360121.
  7. ↑ "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".
  8. ↑ Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi:10.1158/1541-7786.MCR-08-0141. PMID 18819931.

Further reading

  • Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.
  • Wathelet MG, Clauss IM, Content J, Huez GA (1988). "Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses". Eur. J. Biochem. 174 (2): 323–9. doi:10.1111/j.1432-1033.1988.tb14101.x. PMID 2454816.
  • Ulker N, Zhang X, Samuel CE (1988). "Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component". J. Biol. Chem. 262 (35): 16798–803. PMID 3119591.
  • Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE (1987). "Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8929–33. doi:10.1073/pnas.83.23.8929. PMC 387047. PMID 3466167.
  • Zhu H, Cong JP, Shenk T (1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13985–90. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
  • Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, Filiukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. PMID 12708317.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi:10.1074/jbc.M605771200. PMID 16973618.
  • Saha S, Sugumar P, Bhandari P, Rangarajan PN (2006). "Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein". J. Gen. Virol. 87 (Pt 11): 3285–9. doi:10.1099/vir.0.82107-0. PMID 17030862.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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