IFI27

IFI27
Identifiers
Aliases	IFI27, FAM14D, ISG12, ISG12A, P27, interferon alpha inducible protein 27
External IDs	HomoloGene: 128815 GeneCards: IFI27
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	94,116,698 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• RNA polymerase II activating transcription factor binding; • lamin binding; • molecular function; • protein binding; • identical protein binding;
Cellular component	• integral component of membrane; • mitochondrial outer membrane; • nuclear inner membrane; • membrane; • mitochondrion; • nuclear envelope; • mitochondrial membrane;
Biological process	• apoptotic signaling pathway; • negative regulation of transcription from RNA polymerase II promoter; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • type I interferon signaling pathway; • regulation of protein export from nucleus; • apoptotic process; • proteasome-mediated ubiquitin-dependent protein catabolic process; • modulation by host of viral genome replication; • innate immune response; • defense response to virus; • protein K48-linked ubiquitination; • extrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3429
	n/a
	ENSG00000165949; ENSG00000275214
	n/a
	P40305
	n/a
NM_005532; NM_001130080; NM_001288952; NM_001288954; NM_001288956;
	NM_001288957; NM_001288958; NM_001288959; NM_001288960; NM_001288995
	n/a
NP_001123552; NP_001275881; NP_001275883; NP_001275885; NP_001275886;
	NP_001275887; NP_001275888; NP_001275889; NP_001275924; NP_005523
	n/a
	Wikidata
View/Edit Human

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.^[3]^[4]

References

1 2 3 ENSG00000275214 GRCh38: Ensembl release 89: ENSG00000165949, ENSG00000275214 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Rasmussen UB, Wolf C, Mattei MG, Chenard MP, Bellocq JP, Chambon P, Rio MC, Basset P (Sep 1993). "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma". Cancer Research. 53 (17): 4096–101. PMID 8358738.
↑ "Entrez Gene: IFI27 interferon, alpha-inducible protein 27".

Taulés M, Rius E, Talaya D, López-Girona A, Bachs O, Agell N (Dec 1998). "Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1". The Journal of Biological Chemistry. 273 (50): 33279–86. doi:10.1074/jbc.273.50.33279. PMID 9837900.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Martensen PM, Søgaard TM, Gjermandsen IM, Buttenschøn HN, Rossing AB, Bonnevie-Nielsen V, Rosada C, Simonsen JL, Justesen J (Nov 2001). "The interferon alpha induced protein ISG12 is localized to the nuclear membrane". European Journal of Biochemistry / FEBS. 268 (22): 5947–54. doi:10.1046/j.0014-2956.2001.02545.x. PMID 11722583.
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Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
Smidt KC, Hansen LL, Søgaard TM, Petersen LK, Knudsen UB, Martensen PM (Jul 2003). "A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene". Biochimica et Biophysica Acta. 1638 (3): 227–34. doi:10.1016/s0925-4439(03)00087-5. PMID 12878323.
Taguchi T, Kato Y, Baba Y, Nishimura G, Tanigaki Y, Horiuchi C, Mochimatsu I, Tsukuda M (Feb 2004). "Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas". Oncology Reports. 11 (2): 421–6. doi:10.3892/or.11.2.421. PMID 14719078.
Parker N, Porter AC (Jan 2004). "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12". BMC Genomics. 5 (1): 8. doi:10.1186/1471-2164-5-8. PMC 343271. PMID 14728724.
Namciu SJ, Friedman RD, Marsden MD, Sarausad LM, Jasoni CL, Fournier RE (Mar 2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mammalian Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Fjaerli HO, Bukholm G, Krog A, Skjaeret C, Holden M, Nakstad B (2007). "Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis". BMC Infectious Diseases. 6: 175. doi:10.1186/1471-2334-6-175. PMC 1713240. PMID 17166282.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000275214 GRCh38: Ensembl release 89: ENSG00000165949, ENSG00000275214 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[pmid8358738-3] Rasmussen UB, Wolf C, Mattei MG, Chenard MP, Bellocq JP, Chambon P, Rio MC, Basset P (Sep 1993). "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma". Cancer Research. 53 (17): 4096–101. PMID 8358738.

[entrez-4] "Entrez Gene: IFI27 interferon, alpha-inducible protein 27".

IFI27

References

Further reading