Hes family bhlh transcription factor 2

HES2
Identifiers
Aliases	HES2, bHLHb40, hes family bHLH transcription factor 2
External IDs	MGI: 1098624 HomoloGene: 22455 GeneCards: HES2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	6,424,670 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	152,162,469 bp[2]
Gene ontology
Molecular function	• DNA binding; • double-stranded DNA binding; • transcription factor binding; • protein dimerization activity; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Cellular component	• cell nucleus;
Biological process	• negative regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter; • somitogenesis; • Notch signaling pathway; • cell differentiation; • regulation of neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	54626
	15206
	ENSG00000069812
	ENSMUSG00000028940
	Q9Y543
	O54792
	NM_019089
	NM_001301805; NM_008236
	NP_061962
	NP_001288734; NP_032262
	Wikidata
View/Edit Human	View/Edit Mouse

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.^[5]

References

Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950.
Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.