Haplogroup Q-M346

Haplogroup Q-M346
Possible place of origin	Eurasia
Ancestor	Q-MEH2[1]
Descendants	Q-L54, Q-M323[1]
Defining mutations	L56, L57, M346 [1]

Haplogroup Q-M346 is a subclade of Y-DNA Haplogroup Q. Haplogroup Q-M346 is defined by the presence of the M346 Single Nucleotide Polymorphism (SNP).

Origin and distribution

Q-M346 was discovered in Central Asia and announced in Sengupta 2006.^[2] A latter paper suggested that its ancestral state was isolated to India,^[3] but this has since been refuted by its presence in West Asia,^[4] Europe and the Americas.^[5]

Asia

Q-M346 has a wide distribution across much of Asia.^[6]^[7]^[8]^[9]

Population	Paper	N	Percentage	SNP Tested
Altaians	Malyarchuk 2011 ^[6]	23/89	~25.8%	M346
Khakassians	Malyarchuk 2011 ^[6]	4/64	~6.3%	M346
Todjins	Malyarchuk 2011 ^[6]	10/26	~38.5%	M346
Tuvinians	Malyarchuk 2011 ^[6]	41/108	~38.0%	M346
Sojots	Malyarchuk 2011 ^[6]	2/28	~7.1%	M346
Kalmyks	Malyarchuk 2011 ^[6]	1/60	~1.7%	M346
Halba	Sengupta 2006 ^[2]	1/21	~4.76%	M346
Makrani	Sengupta 2006 ^[2]	1/20	~5.00%	M346
Pathan	Sengupta 2006 ^[2]	2/21	~5.00%	M346
Brahmin (Uttar Pradesh)	Sengupta 2006 ^[2]	1/14	~7.14%	M346
Vellalar	Sengupta 2006 ^[2]	1/31	~3.23%	M346
Pakistan	Abu-Amero 2009 ^[7]	3/176	~1.70%	M346
Kazakhs (Southwest Altai)	Dulik 2011 ^[8]	1/30	~3.33%	M346
Chelkan	Dulik 2012 ^[9]	15/25	~60.00%	M346
Tubalar	Dulik 2012 ^[9]	10/27	~37.00%	M346

The Americas

In the Americas, the founding paternal lineages include those who are Q-M346 but do not belong to the Q-M3 lineage.^[5]^[10]

Population	Paper	N	Percentage	SNP Tested
Enxet	Bailliet 2009 ^[5]	7/24	~29.20%	M346
Ayoreo	Bailliet 2009 ^[5]	2/9	~22.20%	M346
Wichi	Bailliet 2009 ^[5]	1/120	~0.80%	M346
Mocovi	Bailliet 2009 ^[5]	2/40	~5.00%	M346
Mapuche	Bailliet 2009 ^[5]	1/26	~3.80%	M346
Salta	Bailliet 2009 ^[5]	3/72	~4.80%	M346
Cordoba	Bailliet 2009 ^[5]	1/156	~0.60%	M346
Huilliche	Bailliet 2009 ^[5]	1/26	~3.80%	M346
La Paz	Bailliet 2009 ^[5]	1/29	~3.40%	M346
Tarija	Bailliet 2009 ^[5]	4/72	~5.50%	M346

Associated SNPs

Q-M346 is marked by the presence of the M346 SNP. Since the discovery of M346 several additional SNPs have been found to also be associated with Q-M346. These SNP's include: L56 and L57. These SNPs appear to be "parallel" to M346.^[1]

Subgroups

This is Thomas Krahn at the Genomic Research Center's Draft tree Proposed Tree for haplogroup Q-M346. The first three levels of subclades are shown. Additional detail is provided on the linked branch article pages.^[1]

Q-MEH2 MEH2, L472, L528
- Q-M346 M346, L56, L57, L474, L892, L942
  - Q-M323 M323
  - Q-L717 L717, L718
  - Q-L940 L940
    - Q-L527 L527, L529, L639
    - Q-L933 L933, L938, L941
  - Q-L53 L53, L55, L213, L331, L475, L476
    - Q-L54 L54

References

1 2 3 4 5 Krahn, Thomas. "FTDNA Draft Y-DNA Tree (AKA YTree)". Family Tree DNA. Archived from the original on 2015-08-15. Retrieved 2012. Check date values in: |accessdate= (help)
1 2 3 4 5 6 Sengupta, Sanghamitra; Zhivotovsky, Lev A.; King, Roy; Mehdi, S.Q.; Edmonds, Christopher A.; Chow, Cheryl-Emiliane T.; Lin, Alice A.; Mitra, Mitashree; Sil, Samir K. (2006). "Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists". The American Journal of Human Genetics. 78 (2): 202–21. doi:10.1086/499411. PMC 1380230. PMID 16400607.
↑ Sharma, Swarkar; Rai, Ekta; Bhat, Audesh K; Bhanwer, Amarjit S; Bamezai, Rameshwar NK (2007). "A novel subgroup Q5 of human Y-chromosomal haplogroup Q in India". BMC Evolutionary Biology. 7: 232. doi:10.1186/1471-2148-7-232. PMC 2258157. PMID 18021436.
↑ Abu-Amero, Khaled K; Hellani, Ali; González, Ana M; Larruga, Jose M; Cabrera, Vicente M; Underhill, Peter A (2009). "Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions". BMC Genetics. 10: 59. doi:10.1186/1471-2156-10-59. PMC 2759955. PMID 19772609.
1 2 3 4 5 6 7 8 9 10 11 12 Bailliet, Graciela; Ramallo, Virginia; Muzzio, Marina; García, Angelina; Santos, María R.; Alfaro, Emma L.; Dipierri, José E.; Salceda, Susana; Carnese, Francisco R. (2009). "Brief communication: Restricted geographic distribution for Y-Q* paragroup in South America". American Journal of Physical Anthropology. 140 (3): 578–82. doi:10.1002/ajpa.21133. PMID 19591214.
1 2 3 4 5 6 7 Malyarchuk, Boris; Derenko, Miroslava; Denisova, Galina; Maksimov, Arkady; Wozniak, Marcin; Grzybowski, Tomasz; Dambueva, Irina; Zakharov, Ilya (2011). "Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a". Journal of Human Genetics. 56 (8): 583–8. doi:10.1038/jhg.2011.64. PMID 21677663.
1 2 K. Abu-Amero, Khaled; et al. (2009). "Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions". BMC Genetics. 10: 59. doi:10.1186/1471-2156-10-59. PMC 2759955. PMID 19772609.
1 2 Dulik, Matthew C.; Osipova, Ludmila P.; Schurr, Theodore G. (2011). Kayser, Manfred, ed. "Y-Chromosome Variation in Altaian Kazakhs Reveals a Common Paternal Gene Pool for Kazakhs and the Influence of Mongolian Expansions". PLoS ONE. 6 (3): e17548. doi:10.1371/journal.pone.0017548. PMC 3055870. PMID 21412412.
1 2 3 Dulik, Matthew C.; Zhadanov, Sergey I.; Osipova, Ludmila P.; Askapuli, Ayken; Gau, Lydia; Gokcumen, Omer; Rubinstein, Samara; Schurr, Theodore G. (2012). "Mitochondrial DNA and Y Chromosome Variation Provides Evidence for a Recent Common Ancestry between Native Americans and Indigenous Altaians". The American Journal of Human Genetics. 90 (2): 229–46. doi:10.1016/j.ajhg.2011.12.014. PMC 3276666. PMID 22281367.
↑ Bisso-Machado, Rafael; Jota, Marilza S.; Ramallo, Virginia; Paixão-Côrtes, Vanessa R.; Lacerda, Daniela R.; Salzano, Francisco M.; Bonatto, Sandro L.; Santos, Fabrício R.; Bortolini, Maria Cátira (2011). "Distribution of Y-chromosome q lineages in native americans". American Journal of Human Biology. 23 (4): 563–6. doi:10.1002/ajhb.21173. PMID 21544893.

External links

The Y-DNA Haplogroup Q Project

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[vanOven2014-11] Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation. 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809.

[ISOGG2015-12] International Society of Genetic Genealogy (ISOGG; 2015), Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)

[A0-T-13] Haplogroup A0-T is also known as A-L1085 (and previously as A0'1'2'3'4).

[A1-14] Haplogroup A1 is also known as A1'2'3'4.

[LT-15] Haplogroup LT (L298/P326) is also known as Haplogroup K1.

[K2-16] Between 2002 and 2008, Haplogroup T-M184 was known as "Haplogroup K2". That name has since been re-assigned to K-M526, the sibling of Haplogroup LT.

[K2a-17] Haplogroup K2a (M2308) and its primary subclade K-M2313 were separated from Haplogroup NO (F549) in 2016. (This followed the publication of: Poznik GD, Xue Y, Mendez FL, et al. (2016). "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences". Nature Genetics. 48 (6): 593–9. doi:10.1038/ng.3559. PMC 4884158. PMID 27111036. In the past, other haplogroups, including NO (M214) and K2e had also been identified with the name "K2a".

[K2b-18] Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.

[K2e-19] Haplogroup K2e (K-M147) was previously known as "Haplogroup X" and "K2a" (but is a sibling subclade of the present K2a).

[K-M2313-20] K-M2313*, which as yet has no phylogenetic name, has been documented in two living individuals, who have ethnic ties to India and South East Asia. In addition, K-Y28299, which appears to be a primary branch of K-M2313, has been found in three living individuals from India. See: Poznik op. cit.; YFull YTree v5.08, 2017, "K-M2335", and; PhyloTree, 2017, "Details of the Y-SNP markers included in the minimal Y tree" (Access date of these pages: 9 December 2017)

[K2b1-21] Haplogroup K2b1 (P397/P399) is also known as Haplogroup MS, but has a broader and more complex internal structure.

[P-22] Haplogroup P (P295) is also klnown as K2b2.

[S-23] Haplogroup S, as of 2017, is also known as K2b1a. (Previously the name Haplogroup S was assigned to K2b1a4.)

[M-24] Haplogroup M, as of 2017, is also known as K2b1b. (Previously the name Haplogroup M was assigned to K2b1d.)

[ThomasDraftTree-1] 1 2 3 4 5 Krahn, Thomas. "FTDNA Draft Y-DNA Tree (AKA YTree)". Family Tree DNA. Archived from the original on 2015-08-15. Retrieved 2012. Check date values in: |accessdate= (help)

[Sengupta2006-2] 1 2 3 4 5 6 Sengupta, Sanghamitra; Zhivotovsky, Lev A.; King, Roy; Mehdi, S.Q.; Edmonds, Christopher A.; Chow, Cheryl-Emiliane T.; Lin, Alice A.; Mitra, Mitashree; Sil, Samir K. (2006). "Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists". The American Journal of Human Genetics. 78 (2): 202–21. doi:10.1086/499411. PMC 1380230. PMID 16400607.

[Sharma2007-3] Sharma, Swarkar; Rai, Ekta; Bhat, Audesh K; Bhanwer, Amarjit S; Bamezai, Rameshwar NK (2007). "A novel subgroup Q5 of human Y-chromosomal haplogroup Q in India". BMC Evolutionary Biology. 7: 232. doi:10.1186/1471-2148-7-232. PMC 2258157. PMID 18021436.

[Abu-Amero2007-4] Abu-Amero, Khaled K; Hellani, Ali; González, Ana M; Larruga, Jose M; Cabrera, Vicente M; Underhill, Peter A (2009). "Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions". BMC Genetics. 10: 59. doi:10.1186/1471-2156-10-59. PMC 2759955. PMID 19772609.

[Bailliet2009-5] 1 2 3 4 5 6 7 8 9 10 11 12 Bailliet, Graciela; Ramallo, Virginia; Muzzio, Marina; García, Angelina; Santos, María R.; Alfaro, Emma L.; Dipierri, José E.; Salceda, Susana; Carnese, Francisco R. (2009). "Brief communication: Restricted geographic distribution for Y-Q* paragroup in South America". American Journal of Physical Anthropology. 140 (3): 578–82. doi:10.1002/ajpa.21133. PMID 19591214.

[Malyarchuk2011-6] 1 2 3 4 5 6 7 Malyarchuk, Boris; Derenko, Miroslava; Denisova, Galina; Maksimov, Arkady; Wozniak, Marcin; Grzybowski, Tomasz; Dambueva, Irina; Zakharov, Ilya (2011). "Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a". Journal of Human Genetics. 56 (8): 583–8. doi:10.1038/jhg.2011.64. PMID 21677663.

[Abu-Amero2009-7] 1 2 K. Abu-Amero, Khaled; et al. (2009). "Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions". BMC Genetics. 10: 59. doi:10.1186/1471-2156-10-59. PMC 2759955. PMID 19772609.

[Dulik2011-8] 1 2 Dulik, Matthew C.; Osipova, Ludmila P.; Schurr, Theodore G. (2011). Kayser, Manfred, ed. "Y-Chromosome Variation in Altaian Kazakhs Reveals a Common Paternal Gene Pool for Kazakhs and the Influence of Mongolian Expansions". PLoS ONE. 6 (3): e17548. doi:10.1371/journal.pone.0017548. PMC 3055870. PMID 21412412.

[Dulik2012-9] 1 2 3 Dulik, Matthew C.; Zhadanov, Sergey I.; Osipova, Ludmila P.; Askapuli, Ayken; Gau, Lydia; Gokcumen, Omer; Rubinstein, Samara; Schurr, Theodore G. (2012). "Mitochondrial DNA and Y Chromosome Variation Provides Evidence for a Recent Common Ancestry between Native Americans and Indigenous Altaians". The American Journal of Human Genetics. 90 (2): 229–46. doi:10.1016/j.ajhg.2011.12.014. PMC 3276666. PMID 22281367.

[Bisso-Machado2011-10] Bisso-Machado, Rafael; Jota, Marilza S.; Ramallo, Virginia; Paixão-Côrtes, Vanessa R.; Lacerda, Daniela R.; Salzano, Francisco M.; Bonatto, Sandro L.; Santos, Fabrício R.; Bortolini, Maria Cátira (2011). "Distribution of Y-chromosome q lineages in native americans". American Journal of Human Biology. 23 (4): 563–6. doi:10.1002/ajhb.21173. PMID 21544893.