HOOK2

HOOK2
Identifiers
AliasesHOOK2, HK2, hook microtubule-tethering protein 2, hook microtubule tethering protein 2
External IDsMGI: 2181664 HomoloGene: 8332 GeneCards: HOOK2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.13Start12,763,003 bp[1]
End12,872,740 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

29911

170833

Ensembl

ENSG00000095066

ENSMUSG00000052566

UniProt

Q96ED9

Q7TMK6

RefSeq (mRNA)

NM_001100176
NM_013312

NM_001167991
NM_133255
NM_001363497
NM_001363498

RefSeq (protein)

NP_001093646
NP_037444

NP_001161463
NP_573518
NP_001350426
NP_001350427

Location (UCSC)Chr 19: 12.76 – 12.87 MbChr 8: 84.99 – 85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Hook homolog 2 (HK2) is a protein[5] that in humans is encoded by the HOOK2 gene.[6][7]

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000095066 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052566 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. PMC 1460498. PMID 9927460.
  6. ↑ Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
  7. 1 2 "Entrez Gene: hook homolog 2 (Drosophila)".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex". Mol. Biol. Cell. 19 (12): 5059–71. doi:10.1091/mbc.E08-05-0473. PMC 2592673. PMID 18799622.
  • Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome". Mol. Biol. Cell. 20 (22): 4790–803. doi:10.1091/mbc.E09-07-0560. PMC 2777108. PMID 19793914.
  • Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMC 1896156. PMID 17540036.
  • Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function". Traffic. 8 (1): 32–46. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400.
  • Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.


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