HNRPAB

HNRNPAB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPAB, ABBP1, HNRPAB, heterogeneous nuclear ribonucleoprotein A/B
External IDsMGI: 1330294 HomoloGene: 74950 GeneCards: HNRNPAB
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q35.3Start178,204,507 bp[1]
End178,211,163 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3182

15384

Ensembl

ENSG00000197451

ENSMUSG00000020358

UniProt

Q99729

Q99020

RefSeq (mRNA)

NM_031266
NM_004499

NM_001048061
NM_010448

RefSeq (protein)

NP_004490
NP_112556

NP_001041526
NP_034578

Location (UCSC)Chr 5: 178.2 – 178.21 MbChr 11: 51.6 – 51.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRPAB, is a protein which in humans is encoded by the HNRPAB gene.[5] Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B,[6] it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.[7][8]

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

Interactions

HNRPAB has been shown to interact with TP63.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197451 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020358 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: HNRPAB heterogeneous nuclear ribonucleoprotein A/B".
  6. ↑ Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Lett. 290 (1–2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314.
  7. ↑ Akindahunsi AA, Bandiera A, Manzini G (February 2005). "Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences". Comput Biol Chem. 29 (1): 13–23. doi:10.1016/j.compbiolchem.2004.11.002. PMID 15680582.
  8. ↑ Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW (April 2005). "Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis". Dev. Cell. 8 (4): 505–15. doi:10.1016/j.devcel.2005.01.012. PMID 15809033.
  9. ↑ Fomenkov, Alexey; Huang Yi-Ping; Topaloglu Ozlem; Brechman Anna; Osada Motonobo; Fomenkova Tanya; Yuriditsky Eugene; Trink Barry; Sidransky David; Ratovitski Edward (Jun 2003). "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome". J. Biol. Chem. United States. 278 (26): 23906–14. doi:10.1074/jbc.M300746200. ISSN 0021-9258. PMID 12692135.

Further reading

  • Khan FA, Jaiswal AK, Szer W (1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Lett. 290 (1–2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
  • Lau PP, Zhu HJ, Nakamuta M, Chan L (1997). "Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing". J. Biol. Chem. 272 (3): 1452–5. doi:10.1074/jbc.272.3.1452. PMID 8999813.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hay DC, Kemp GD, Dargemont C, Hay RT (2001). "Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription". Mol. Cell. Biol. 21 (10): 3482–90. doi:10.1128/MCB.21.10.3482-3490.2001. PMC 100270. PMID 11313474.
  • Lau PP, Chang BH, Chan L (2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochem. Biophys. Res. Commun. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
  • Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock". RNA. 7 (9): 1348–61. doi:10.1017/S1355838201016089. PMC 1370177. PMID 11565755. (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
  • Percipalle P, Jonsson A, Nashchekin D, et al. (2002). "Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins". Nucleic Acids Res. 30 (8): 1725–34. doi:10.1093/nar/30.8.1725. PMC 113215. PMID 11937625.
  • Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fomenkov A, Huang YP, Topaloglu O, et al. (2003). "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome". J. Biol. Chem. 278 (26): 23906–14. doi:10.1074/jbc.M300746200. PMID 12692135.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang S, Schlott B, Görlach M, Grosse F (2004). "DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner". Nucleic Acids Res. 32 (1): 1–10. doi:10.1093/nar/gkg933. PMC 373260. PMID 14704337.
  • Gao C, Guo H, Wei J, et al. (2004). "S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages". J. Biol. Chem. 279 (12): 11236–43. doi:10.1074/jbc.M313385200. PMC 5336185. PMID 14722087.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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