Histone H2A type 1-J is a protein that in humans is encoded by the HIST1H2AJ gene.[5][6][7]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[7]
Further reading
- Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M (1996). "Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay". Biochim. Biophys. Acta. 1296 (2): 219–27. doi:10.1016/0167-4838(96)00072-6. PMID 8814229.
- El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
- Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132.
- Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
- Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
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1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT 1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION 1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE 1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution 1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution 1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution 1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA 1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants 1s32: Molecular Recognition of the Nucleosomal 'Supergroove' 1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution 1zbb: Structure of the 4_601_167 Tetranucleosome 1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core 2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione 2cv5: Crystal structure of human nucleosome core particle 2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes 2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element 2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN 2nzd: Nucleosome core particle containing 145 bp of DNA |