HERC1

HERC1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHERC1, p532, p619, HECT and RLD domain containing E3 ubiquitin protein ligase family member 1, MDFPMR
External IDsMGI: 2384589 HomoloGene: 31207 GeneCards: HERC1
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q22.31Start63,608,618 bp[1]
End63,833,942 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8925

235439

Ensembl

ENSG00000103657

ENSMUSG00000038664

UniProt

Q15751

n/a

RefSeq (mRNA)

NM_003922

NM_145617

RefSeq (protein)

NP_003913

n/a

Location (UCSC)Chr 15: 63.61 – 63.83 MbChr 9: 66.35 – 66.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable E3 ubiquitin-protein ligase HERC1 is an enzyme that in humans is encoded by the HERC1 gene.[5][6][7]

The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport processes[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103657 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038664 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M (Dec 1996). "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins". EMBO J. 15 (16): 4262–73. PMC 452152. PMID 8861955.
  6. ↑ Rosa JL, Barbacid M (Aug 1997). "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70". Oncogene. 15 (1): 1–6. doi:10.1038/sj.onc.1201170. PMID 9233772.
  7. 1 2 "Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Garcia-Gonzalo FR, Bartrons R, Ventura F, Rosa JL (2005). "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins". FEBS Lett. 579 (2): 343–8. doi:10.1016/j.febslet.2004.11.095. PMID 15642342.
  • Garcia-Gonzalo FR, Muñoz P, González E, et al. (2004). "The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells". FEBS Lett. 559 (1–3): 77–83. doi:10.1016/S0014-5793(04)00030-4. PMID 14960311.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Garcia-Gonzalo FR, Cruz C, Muñoz P, et al. (2003). "Interaction between HERC1 and M2-type pyruvate kinase". FEBS Lett. 539 (1–3): 78–84. doi:10.1016/S0014-5793(03)00205-9. PMID 12650930.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cruz C, Paladugu A, Ventura F, et al. (1999). "Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 86 (1): 68–9. doi:10.1159/000015414. PMID 10516438.
  • Ji Y, Walkowicz MJ, Buiting K, et al. (1999). "Prader-Willi". Hum. Mol. Genet. 8 (3): 533–42. doi:10.1093/hmg/8.3.533. PMID 9949213.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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