HELLS

HELLS
Identifiers
Aliases	HELLS, LSH, PASG, SMARCA6, Nbla10143, ICF4, helicase, lymphoid-specific, helicase, lymphoid specific
External IDs	MGI: 106209 HomoloGene: 50037 GeneCards: HELLS
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	94,613,905 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	38,971,051 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • protein binding; • ATP binding; • helicase activity; • hydrolase activity;
Cellular component	• pericentric heterochromatin; • chromosome, centromeric region; • cell nucleus;
Biological process	• lymphocyte proliferation; • cell cycle; • pericentric heterochromatin assembly; • maintenance of DNA methylation; • methylation-dependent chromatin silencing; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • cell division; • multicellular organism development; • metabolism;
	Sources:Amigo / QuickGO
Orthologs
	3070
	15201
	ENSG00000119969
	ENSMUSG00000025001
	Q9NRZ9; Q76H82
	Q60848
NM_018063; NM_001289067; NM_001289068; NM_001289069; NM_001289070;
	NM_001289071; NM_001289072; NM_001289073; NM_001289074; NM_001289075
	NM_008234
NP_001275996; NP_001275997; NP_001275998; NP_001275999; NP_001276000;
	NP_001276001; NP_001276002; NP_001276003; NP_001276004; NP_060533; NP_001276000.1; NP_001276000.1
	NP_032260
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene.^[5]^[6]^[7]

This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119969 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025001 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Geiman TM, Durum SK, Muegge K (Feb 1999). "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)". Genomics. 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.
↑ Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ (Aug 2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res. 60 (13): 3612–22. PMID 10910076.
1 2 "Entrez Gene: HELLS helicase, lymphoid-specific".

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sun LQ, Lee DW, Zhang Q, et al. (2004). "Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG". Genes Dev. 18 (9): 1035–46. doi:10.1101/gad.1176104. PMC 406293. PMID 15105378.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Yano M, Ouchida M, Shigematsu H, et al. (2004). "Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer". Int. J. Cancer. 112 (1): 8–13. doi:10.1002/ijc.20407. PMID 15305370.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119969 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025001 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9878251-5] Geiman TM, Durum SK, Muegge K (Feb 1999). "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)". Genomics. 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.

[pmid10910076-6] Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ (Aug 2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res. 60 (13): 3612–22. PMID 10910076.

[entrez-7] 1 2 "Entrez Gene: HELLS helicase, lymphoid-specific".

HELLS

References

Further reading