HABP2

HABP2
Identifiers
AliasesHABP2, FSAP, HABP, HGFAL, PHBP, NMTC5, hyaluronan binding protein 2
External IDsMGI: 1196378 HomoloGene: 3050 GeneCards: HABP2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q25.3Start113,550,837 bp[1]
End113,589,602 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3026

226243

Ensembl

ENSG00000148702

ENSMUSG00000025075

UniProt

Q14520

Q8K0D2

RefSeq (mRNA)

NM_004132
NM_001177660

NM_146101
NM_001329935
NM_001329936

RefSeq (protein)

NP_001171131
NP_004123

NP_001316864
NP_001316865
NP_666213

Location (UCSC)Chr 10: 113.55 – 113.59 MbChr 19: 56.29 – 56.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene.[5][6][7]

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000148702 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025075 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M (Dec 1996). "Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem. 119 (6): 1157–65. doi:10.1093/oxfordjournals.jbchem.a021362. PMID 8827452.
  6. ↑ Romisch J (Nov 2002). "Factor VII activating protease (FSAP): a novel protease in hemostasis". Biol Chem. 383 (7–8): 1119–24. doi:10.1515/BC.2002.121. PMID 12437095.
  7. 1 2 "Entrez Gene: HABP2 hyaluronan binding protein 2".

Further reading

  • Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.
  • Sumiya J, Asakawa S, Tobe T, et al. (1998). "Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2)". J. Biochem. 122 (5): 983–90. doi:10.1093/oxfordjournals.jbchem.a021861. PMID 9443814.
  • Choi-Miura NH, Yoda M, Saito K, et al. (2001). "Identification of the substrates for plasma hyaluronan binding protein". Biol. Pharm. Bull. 24 (2): 140–3. doi:10.1248/bpb.24.140. PMID 11217080.
  • Choi-Miura NH, Takahashi K, Yoda M, et al. (2001). "Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein". Biol. Pharm. Bull. 24 (5): 448–52. doi:10.1248/bpb.24.448. PMID 11379758.
  • Roemisch J, Feussner A, Nerlich C, et al. (2003). "The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)". Blood Coagul. Fibrinolysis. 13 (5): 433–41. doi:10.1097/00001721-200207000-00008. PMID 12138371.
  • Wang KK, Liu N, Radulovich N, et al. (2002). "Novel candidate tumor marker genes for lung adenocarcinoma". Oncogene. 21 (49): 7598–604. doi:10.1038/sj.onc.1205953. PMID 12386823.
  • Etscheid M, Beer N, Fink E, et al. (2003). "The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin". Biol. Chem. 383 (10): 1633–43. doi:10.1515/BC.2002.184. PMID 12452440.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Willeit J, Kiechl S, Weimer T, et al. (2003). "Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis". Circulation. 107 (5): 667–70. doi:10.1161/01.CIR.0000055189.18831.B1. PMID 12578864.
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
  • Hoppe B, Tolou F, Radtke H, et al. (2005). "Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism". Blood. 105 (4): 1549–51. doi:10.1182/blood-2004-08-3328. PMID 15486068.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ireland H, Miller GJ, Webb KE, et al. (2005). "The factor VII activating protease G511E (Marburg) variant and cardiovascular risk". Thromb. Haemost. 92 (5): 986–92. doi:10.1267/THRO04050986. PMID 15543324.
  • Nakazawa F, Kannemeier C, Shibamiya A, et al. (2005). "Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)". Biochem. J. 385 (Pt 3): 831–8. doi:10.1042/BJ20041021. PMC 1134760. PMID 15654766.
  • van Minkelen R, de Visser MC, Vos HL, et al. (2005). "The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis". Blood. 105 (12): 4898, author reply 4899. doi:10.1182/blood-2005-02-0576. PMID 15933067.
  • Etscheid M, Beer N, Dodt J (2006). "The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration". Cell. Signal. 17 (12): 1486–94. doi:10.1016/j.cellsig.2005.03.007. PMID 16153533.


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