Gurmarin
Gurmarin | |||||||||
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![]() Structure of gurmarin, a sweet taste-suppressing polypeptide.[1] | |||||||||
Identifiers | |||||||||
Symbol | Gurmarin | ||||||||
Pfam | PF11410 | ||||||||
InterPro | IPR010485 | ||||||||
SCOP | 1gur | ||||||||
SUPERFAMILY | 1gur | ||||||||
OPM superfamily | 112 | ||||||||
OPM protein | 1c4e | ||||||||
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Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre (Gurmar). It has been utilised as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet tastants in rats.[2] As a sweet-taste-suppressing protein, gurmarin is only active on rodent sweet taste receptors but not on that of humans. ref: Appl Microbiol Biotechnol. 2012 Nov;96(3):619-30
References
- ↑ Arai K, Ishima R, Morikawa S, et al. (April 1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425.
- ↑ Arai K, Aimoto S, Morikawa S, Yoshimura S, Ishima R, Imoto T, Miyasaka A, Akasaka K (1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425.
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