Guoping Feng

Guoping Feng is the Poitras Professor of Neuroscience at the McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT^[3][4] and member of the Stanley Center for Psychiatric Research at Broad Institute most notable for studying the synaptic mechanisms underlying psychiatric disease.^[5] In addition to developing many genetic-based imaging tools for the study of molecular mechanisms in the brain,^[6] he has generated and characterized rodent models of obsessive-compulsive disorder,^[7][8] autism spectrum disorders,^[9] and schizophrenia.^[10] Feng has also shown that some autism-like behaviors can be corrected in adult mice by manipulating the expression of the Shank3 gene.^[11]

Selected publications

• Mei Y, Monteiro P, Zhou Y, Kim J, Gao X, Fu Z, Feng G. (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. . Nature doi:10.1038/nature16971
• Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. (2012) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472: 437–442
• Welch, JM., Lu, J., Rodriguiz, RM., Trotta, NC., Peca, J., Ding, J-D., Feliciano, C., Chen, M., Adams, JP., Luo, J., Dudek, SM., Weinberg, RJ., Calakos, N., Wetsel, WC., and Feng, G. (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature 448: 894–900
• Feng G et al. (2000) Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP. Neuron 28: 41–51

References