Guanosine nucleotide dissociation inhibitor
| GDP dissociation inhibitor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | GDI | ||||||||
| Pfam | PF00996 | ||||||||
| InterPro | IPR002005 | ||||||||
| SCOP | 1gnd | ||||||||
| SUPERFAMILY | 1gnd | ||||||||
| |||||||||
A guanosine nucleotide dissociation inhibitor (GDI) binds to the GDP-bound form of Rho and Rab small GTPases and not only prevents exchange (maintaining the small GTPase in an off-state), but also prevents the small GTPase from localizing at the membrane, which is their place of action. This inhibition can be removed by the action of a GDI displacement factor.[1] It also inhibits cdc42 by binding to its tail and preventing its insertion into membranes; hence it cannot trigger WASPs and cannot lead to nucleation of F-actin.
References
- ↑ Dirac-Svejstrup AB, Sumizawa T, Pfeffer SR (February 1997). "Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI". The EMBO Journal. 16 (3): 465–72. doi:10.1093/emboj/16.3.465. PMC 1169650. PMID 9034329.
External links
- Guanine+Nucleotide+Dissociation+Inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH)
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