Glycolipid transfer protein

Glycolipid transfer protein (GLTP)
Identifiers
Symbol GLTP
Pfam PF08718
InterPro IPR014830
OPM superfamily 84
OPM protein 1swx

Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.[1][2]

It was discovered by Raymond J. Metz and Norman S. Radin in 1980 and partially purified and characterized in 1982.[3][4]

Recent reviews on structure and possible function are available.[5][6]

This protein transports primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.

Human proteins containing this domain

GLTP; PLEKHA8; PLEKHA9;

References

  1. ↑ Rao CS, Lin X, Pike HM, Molotkovsky JG, Brown RE (November 2004). "Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses". Biochemistry. 43 (43): 13805–15. doi:10.1021/bi0492197. PMC 2596630. PMID 15504043.
  2. ↑ Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA (January 2006). "Structural evidence for adaptive ligand binding of glycolipid transfer protein". Journal of Molecular Biology. 355 (2): 224–36. doi:10.1016/j.jmb.2005.10.031. PMID 16309699.
  3. ↑ Metz RJ, Radin NS (May 1980). "Glucosylceramide uptake protein from spleen cytosol". The Journal of Biological Chemistry. 255 (10): 4463–7. PMID 7372587.
  4. ↑ Metz RJ, Radin NS (November 1982). "Purification and properties of a cerebroside transfer protein". The Journal of Biological Chemistry. 257 (21): 12901–7. PMID 7130186.
  5. ↑ Mattjus P (January 2009). "Glycolipid transfer proteins and membrane interaction". Biochimica et Biophysica Acta. 1788 (1): 267–72. doi:10.1016/j.bbamem.2008.10.003. PMID 19007748.
  6. ↑ Brown RE, Mattjus P (June 2007). "Glycolipid transfer proteins". Biochimica et Biophysica Acta. 1771 (6): 746–60. doi:10.1016/j.bbalip.2007.01.011. PMC 1986823. PMID 17320476.
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