Glutaurine

Glutaurine

Names
IUPAC name N-(2-Sulfoethyl)-L-glutamine
Other names γ-Glutamyltaurine; γ-L-Glutamyltaurine[1]
Identifiers
CAS Number	56488-60-9 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2106758
ChemSpider	62003
PubChem CID	68759
InChI InChI=1S/C7H14N2O6S/c8-5(7(11)12)1-2-6(10)9-3-4-16(13,14)15/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14,15)/t5-/m0/s1 Key: WGXUDTHMEITUBO-YFKPBYRVSA-N InChI=1/C7H14N2O6S/c8-5(7(11)12)1-2-6(10)9-3-4-16(13,14)15/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14,15)/t5-/m0/s1 Key: WGXUDTHMEITUBO-YFKPBYRVBF
SMILES O=C(NCCS(=O)(=O)O)CC[C@@H](C(=O)O)N
Properties
Chemical formula	C7H14N2O6S
Molar mass	173.1897
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Glutaurine is a chemical compound which is an amide formed from glutamic acid and taurine.

Biological role

Glutaurine, an endogenous compound (KEGG: C05844), has been noted as an antiepileptic, with antiamnesia properties. The dipeptide γ-glutamyltaurine (γ-GT; glutaurine, Litoralon) was discovered in the parathyroid in 1980, and later in the mammalian brain. This led to studies on intrinsic and synthetic taurine peptides, and the suggestion that γ-glutamyltransferase (GGT; γ-glutamyl-transpeptidase) in the brain is responsible for its in vivo formation.^[2]

The versatile molecule mimicks the anxiolytic drug diazepam, and is implicated in phenomena from feline aggression to amphibian metamorphosis, radiation protection and the glutamatergic system in schizophrenic disorders.^[2]

References