Glutathione S-transferase Mu 1

GSTM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GTU, 1XW6, 1XWK, 1YJ6, 2F3M
Identifiers
Aliases	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1
External IDs	MGI: 95861 HomoloGene: 121492 GeneCards: GSTM1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,687,814 bp[1] End 109,709,039 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 107,981,702 bp[2] End 107,986,453 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • enzyme binding • glutathione binding • protein homodimerization activity • transferase activity • glutathione transferase activity Cellular component • cytoplasm • cytosol • intercellular bridge Biological process • xenobiotic catabolic process • nitrobenzene metabolic process • cellular detoxification of nitrogen compound • glutathione metabolic process • metabolism • glutathione derivative biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2944	14863
Ensembl	ENSG00000134184	ENSMUSG00000040562
UniProt	P09488	P15626
RefSeq (mRNA)	NM_000561 NM_146421	NM_008183
RefSeq (protein)	NP_000552 NP_666533	NP_032209
Location (UCSC)	Chr 1: 109.69 – 109.71 Mb	Chr 3: 107.98 – 107.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human Glutathione S-transferase.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.^[5]

References

Further reading