Ganesh Nagaraju

Ganesh Nagaraju
Born India
Residence Bengaluru, Karnataka, India
Nationality Indian
Alma mater
Known for Studies on DNA damage responses, Chromosome instability genetic diseases and Cancer
Awards
  • 2018 Shanti Swarup Bhatnagar Prize in Biological Sciences
  • 2015  N-BIOS Prize
  • 2015 Sir C.V. Raman Young Scientist award from Government of Karnataka
  • 2012 B.M.Birla Science Prize in Biology
  • 2003 Prof. K.V. Giri memorial award for best Ph.D Thesis
Scientific career
Fields
Institutions

Ganesh Nagaraju is an Indian biochemist, geneticist, cancer biologist and an Associate Professor at the Department of Biochemistry of the Indian Institute of Science. He has been studying studying DNA damage responses in mammalian cells, and mechanisms underlying chromosome instability genetic diseases and cancer. He was involved in the development of trans-dichloro oxovanadium (IV) complex of pyrenyl terpyridine, an anti-cancer agent. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, for his contributions to biosciences, in 2015.[1]. In 2018, he has received prestigious Shanti Swarup Bhatnagar prize in Biological Sciences from CSIR.[2] This award is given in recognition of outstanding contributions to Science and Technology, and is considered as one of the highest award for Science in India.

Biography

Harvard Medical School.

Ganesh Nagaraju earned his PhD from the Indian Institute of Science in 2003 and did his post-doctoral research at Harvard Medical School and Beth Israel Deaconess Medical Center.[3] On his return to India in 2007,[4] he joined his alma mater, Indian Institute of Science, where he serves as an associate professor.[5] His research focus is on cancer biology and chromosome instability and his team is involved in developing DNA repair protocols.[6] In 2016, his team developed a novel compound, trans-dichloro oxovanadium(IV) complex of pyrenyl terpyridine, a visible light inducible DNA crosslinker which could be activated by visible light and it showed properties of forming crosslinks in the DNA when cancer cells are exposed to UV-A or visible light, thus protecting the cells against the onset of cancer.[7] His studies have been documented by way of a number of articles[8][note 1] and ResearchGate, an online repository of scientific articles has listed 38 of them.[9] He has delivered invited speeches at several international conferences which included the seminar on Distinct roles of RAD51 paralogs in DNA damage responses held at Centre for DNA Fingerprinting and Diagnostics on October 4, 2016[10] and the Indo-French Conference on Recent Advances in Genome Integrity and Plasticity held at Bengaluru in December 2017.[11] He also hosts several post-doctoral and doctoral researchers at his laboratory.[12]

Awards and honors

The Department of Biotechnology (DBT) of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards in 2015.[1] Prof. K.V.Giri memorial award for best Ph.D Thesis in the year 2003. B.M.Birla Science Prize in Biology for the year 2012. Sir C.V. Raman Young Scientist award from Government of Karnataka for the year 2015. Shanti Swarup Bhantnagar Prize in Biological Sciences for the year 2018.

Selected bibliography

  • Mishra, Anup; Saxena, Sneha; Kaushal, Anjali; Nagaraju, Ganesh (2018-02-01). "RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity of the Mitochondrial Genome". Molecular and Cellular Biology. 38 (3): e00489–17. doi:10.1128/MCB.00489-17.
  • Somyajit, Kumar; Banik, Bhabatosh; Saxena, Sneha; Babu, Sharath; Hande, Manoor Prakash; Chakravarty, Akhil R.; Nagaraju, Ganesh (2016-02-01). "Trans -dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy". Carcinogenesis. 37 (2): 145–156. doi:10.1093/carcin/bgv173.
  • Thakur, Roshan Singh; Basavaraju, Shivakumar; Khanduja, Jasbeer Singh; Muniyappa, K.; Nagaraju, Ganesh (2015-10-02). "Mycobacterium tuberculosis RecG Protein but Not RuvAB or RecA Protein Is Efficient at Remodeling the Stalled Replication Forks IMPLICATIONS FOR MULTIPLE MECHANISMS OF REPLICATION RESTART IN MYCOBACTERIA". Journal of Biological Chemistry. 290 (40): 24119–24139. doi:10.1074/jbc.M115.671164. PMC 4591802.

See also

Notes

  1. ↑ Please see Selected bibliography section

References

  1. 1 2 "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Retrieved 2017-11-20.
  2. ↑ http://ssbprize.gov.in/Content/Detail.aspx?AID=536
  3. ↑ "DNA Repair and Disease Laboratory - Indian Institute of Science". biochem.iisc.ernet.in. 2018-05-14. Retrieved 2018-05-14.
  4. ↑ "Ganesh Nagaraju, Ph.D. profile in India Cancer Research Database". www.incredb.org. 2018-05-14. Retrieved 2018-05-14.
  5. ↑ "Department of Biochemistry". biochem.iisc.ernet.in. 2018-05-14. Retrieved 2018-05-14.
  6. ↑ "Ganesh Nagaraju - Division of Biological Sciences, Indian Institute of Science". bio.iisc.ac.in. 2018-05-14. Retrieved 2018-05-14.
  7. ↑ Taru (2018-05-14). "Breaking Cancer's back: Targeting the DNA". Indian Institute of Science. Retrieved 2018-05-14.
  8. ↑ "On Google Scholar". Google Scholar. 2018-05-14. Retrieved 2018-05-14.
  9. ↑ "On ResearchGate". On ResearchGate. 2018-05-14. Retrieved 2018-05-14.
  10. ↑ "CDFD :: Seminar by Dr Ganesh Nagaraju". www.cdfd.org.in. 2018-05-14. Retrieved 2018-05-14.
  11. ↑ "Indo-French Conference ,Indian Institute of Science (IISc), Bangalore". indo-frenchconference2017.com. 2018-05-14. Retrieved 2018-05-14.
  12. ↑ "DNA Repair and Disease Laboratory - People". biochem.iisc.ernet.in. 2018-05-14. Retrieved 2018-05-14.
  • "Prof. Ganesh Nagaraju awarded the National Bioscience Award for Career Development-2015". www.iisc.ac.in. 2015. Retrieved 2018-05-14.
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