GTPBP1

GTPBP1
Identifiers
AliasesGTPBP1, GP-1, GP1, HSPC018, GTP binding protein 1
External IDsMGI: 109443 HomoloGene: 3165 GeneCards: GTPBP1
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start38,705,723 bp[1]
End38,738,299 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9567

14904

Ensembl

ENSG00000100226

ENSMUSG00000042535

UniProt

O00178

O08582

RefSeq (mRNA)

NM_004286

NM_013818

RefSeq (protein)

NP_004277

NP_038846

Location (UCSC)Chr 22: 38.71 – 38.74 MbChr 15: 79.69 – 79.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.[5][6]

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100226 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042535 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.
  6. 1 2 "Entrez Gene: GTPBP1 GTP binding protein 1".

Further reading

  • Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein". Biochem. J. 336 (2): 381–6. PMC 1219882. PMID 9820815.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
  • Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1". Mol. Cell. Biol. 20 (17): 6195–200. doi:10.1128/MCB.20.17.6195-6200.2000. PMC 86094. PMID 10938096.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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