GPSM2

GPSM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SF4, 4WNE, 4WNF, 4WNG, 5A6C
Identifiers
Aliases	GPSM2, CMCS, DFNB82, LGN, PINS, G-protein signaling modulator 2, G protein signaling modulator 2
External IDs	MGI: 1923373 HomoloGene: 56584 GeneCards: GPSM2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	108,934,545 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	108,722,309 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• G-protein alpha-subunit binding; • nucleotide binding; • protein binding; • GTPase regulator activity; • identical protein binding; • GDP-dissociation inhibitor activity; • dynein complex binding; • protein C-terminus binding; • protein domain specific binding; • protein self-association;
Cellular component	• mitotic spindle pole; • spindle pole; • cytoskeleton; • cytosol; • cytoplasm; • cell cortex region; • cell cortex; • lateral cell cortex; • plasma membrane; • membrane; • lateral plasma membrane; • centrosome; • macromolecular complex;
Biological process	• mitotic spindle organization; • G-protein coupled receptor signaling pathway; • maintenance of centrosome location; • regulation of catalytic activity; • Ran protein signal transduction; • regulation of mitotic spindle organization; • positive regulation of protein localization to cell cortex; • positive regulation of spindle assembly; • cell cycle; • cell division; • establishment of mitotic spindle orientation;
	Sources:Amigo / QuickGO
Orthologs
	29899
	76123
	ENSG00000121957
	ENSMUSG00000027883
	P81274
	Q8VDU0
	NM_013296; NM_001321038; NM_001321039
	NM_029522
NP_001307967; NP_001307968; NP_037428; NP_037428.3; NP_001307967.1;
	NP_001307968.1
	NP_083798
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.^[5]^[6]^[7]

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]^[7]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1^[8] and GNAI2.^[6]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121957 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027883 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
1 2 Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
1 2 "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".
↑ Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
↑ Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

Du Q, Stukenberg PT, Macara IG (2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
Kaushik R, Yu F, Chia W, Yang X, Bahri S (2003). "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem. 280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID 15632202.
Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T (2005). "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population". J. Hypertens. 23 (8): 1497–505. doi:10.1097/01.hjh.0000174606.41651.ae. PMID 16003176.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000121957 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027883 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11832491-5] Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.

[pmid8973305-6] 1 2 Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.

[entrez-7] 1 2 "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".

[pmid11781568-8] Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.

[pmid12748287-9] Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

GPSM2

Function

Interactions

References

Further reading