GPIHBP1

GPIHBP1
Identifiers
AliasesGPIHBP1, GPI-HBP1, HYPL1D, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
External IDsHomoloGene: 18651 GeneCards: GPIHBP1
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start143,213,193 bp[1]
End143,217,170 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

338328

n/a

Ensembl

ENSG00000277494

n/a

UniProt

Q8IV16

n/a

RefSeq (mRNA)

NM_178172
NM_001301772

n/a

RefSeq (protein)

NP_001288701
NP_835466

n/a

Location (UCSC)Chr 8: 143.21 – 143.22 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) also known as high density lipoprotein-binding protein 1 is a protein that in humans is encoded by the GPIHBP1 gene.[3]

Function

Dietary fats are packaged by intestine into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons.[3][4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000277494 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. 1 2 "Entrez Gene: Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1".
  4. ↑ Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG (April 2007). "Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons". Cell Metab. 5 (4): 279–91. doi:10.1016/j.cmet.2007.02.002. PMC 1913910. PMID 17403372.

Further reading

  • Coca-Prieto, I.; Kroupa, O.; Gonzalez-Santos, P.; Magne, J.; Olivecrona, G.; Ehrenborg, E.; Valdivielso, P. (2011). "Childhood-onset chylomicronaemia with reduced plasma lipoprotein lipase activity and mass: Identification of a novelGPIHBP1mutation". Journal of Internal Medicine. 270 (3): 224–228. doi:10.1111/j.1365-2796.2011.02361.x. PMID 21314738.
  • Olivecrona, G.; Ehrenborg, E.; Semb, H.; Makoveichuk, E.; Lindberg, A.; Hayden, M. R.; Gin, P.; Davies, B. S. J.; Weinstein, M. M.; Fong, L. G.; Beigneux, A. P.; Young, S. G.; Olivecrona, T.; Hernell, O. (2009). "Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia". The Journal of Lipid Research. 51 (6): 1535–1545. doi:10.1194/jlr.M002717. PMC 3035517. PMID 20026666.
  • Charriere, S.; Peretti, N.; Bernard, S.; Di Filippo, M.; Sassolas, A.; Merlin, M.; Delay, M.; Debard, C.; Lefai, E.; Lachaux, A.; Moulin, P.; Marcais, C. (2011). "GPIHBP1 C89F Neomutation and Hydrophobic C-Terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia". Journal of Clinical Endocrinology & Metabolism. 96 (10): E1675–E1679. doi:10.1210/jc.2011-1444. PMID 21816778.
  • Gin, P.; Yin, L.; Davies, B. S. J.; Weinstein, M. M.; Ryan, R. O.; Bensadoun, A.; Fong, L. G.; Young, S. G.; Beigneux, A. P. (2008). "The Acidic Domain of GPIHBP1 is Important for the Binding of Lipoprotein Lipase and Chylomicrons". Journal of Biological Chemistry. 283 (43): 29554–29562. doi:10.1074/jbc.M802579200. PMC 2662032. PMID 18713736.
  • Young, S. G.; Davies, B. S. J.; Voss, C. V.; Gin, P.; Weinstein, M. M.; Tontonoz, P.; Reue, K.; Bensadoun, A.; Fong, L. G.; Beigneux, A. P. (2011). "GPIHBP1, an endothelial cell transporter for lipoprotein lipase". The Journal of Lipid Research. 52 (11): 1869–1884. doi:10.1194/jlr.R018689. PMC 3196223. PMID 21844202.
  • Beigneux, A. P.; Franssen, R.; Bensadoun, A.; Gin, P.; Melford, K.; Peter, J.; Walzem, R. L.; Weinstein, M. M.; Davies, B. S. J.; Kuivenhoven, J. A.; Kastelein, J. J. P.; Fong, L. G.; Dallinga-Thie, G. M.; Young, S. G. (2009). "Chylomicronemia with a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase". Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (6): 956–962. doi:10.1161/ATVBAHA.109.186577. PMC 2811263. PMID 19304573.
  • Sonnenburg, W. K.; Yu, D.; Lee, E. C.; Xiong, W.; Gololobov, G.; Key, B.; Gay, J.; Wilganowski, N.; Hu, Y.; Zhao, S.; Schneider, M.; Ding, Z. -M.; Zambrowicz, B. P.; Landes, G.; Powell, D. R.; Desai, U. (2009). "GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4". The Journal of Lipid Research. 50 (12): 2421–2429. doi:10.1194/jlr.M900145-JLR200. PMC 2781314. PMID 19542565.
  • Young, S. G.; Davies, B. S.; Fong, L. G.; Gin, P.; Weinstein, M. M.; Bensadoun, A. ?; Beigneux, A. P. (2007). "GPIHBP1: An endothelial cell molecule important for the lipolytic processing of chylomicrons". Current Opinion in Lipidology. 18 (4): 389–396. doi:10.1097/MOL.0b013e3281527914. PMC 2888298. PMID 17620854.
  • Ruge, T.; Sukonina, V.; Kroupa, O.; Makoveichuk, E.; Lundgren, M.; Svensson, M. K.; Olivecrona, G.; Eriksson, J. W. (2012). "Effects of hyperinsulinemia on lipoprotein lipase, angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects with and without type 2 diabetes mellitus". Metabolism. 61 (5): 652–660. doi:10.1016/j.metabol.2011.09.014. PMID 22078753.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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