In molecular biology, GNAS antisense RNA (non-protein coding), also known as GNAS-AS1, is a long non-coding RNA.It is antisense to the GNAS gene. It is an imprinted gene, expressed only from the paternal allele, suggesting that it may have a role in suppression of the paternal NESP55 allele encoded by GNAS.[2]
Further reading
- Tobi EW, Lumey LH, Talens RP, et al. (2009). "DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific". Hum. Mol. Genet. 18 (21): 4046–53. doi:10.1093/hmg/ddp353. PMC 2758137. PMID 19656776.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Hayward BE, Bonthron DT (2000). "An imprinted antisense transcript at the human GNAS1 locus". Hum. Mol. Genet. 9 (5): 835–41. doi:10.1093/hmg/9.5.835. PMID 10749992.
- Wroe SF, Kelsey G, Skinner JA, et al. (2000). "An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3342–6. doi:10.1073/pnas.050015397. PMC 16241. PMID 10716699.
- Li T, Vu TH, Zeng ZL, et al. (2000). "Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus". Genomics. 69 (3): 295–304. doi:10.1006/geno.2000.6337. PMID 11056047.
- Williamson CM, Skinner JA, Kelsey G, Peters J (2002). "Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster". Mamm. Genome. 13 (2): 74–9. doi:10.1007/s00335-001-2102-2. PMID 11889554.
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